Inflammation scores were blindly determined by examining the histology slides under the microscope as shown in the Fig 5. FI-RSV MN patch delivery with MPL attenuates histopathology after RSV challenge. (A) Inflammation scores around the airways. (B) Inflammation scores around blood vessels. (C) Inflammation scores around interstitial spaces. (D) Stained lung sections were scored for bronchiolar mucus production as the percentages of PAS positives. Results (n = 5) are presented as mean ± SEM. Statistical significances were performed by one-way ANOVA and Tukey’s multiple-comparison tests in GraphPad Prism; *** p<0.001, **p<0.01, *p<0.05.</p
<p>(A) Inflammatory cell counts and classification in BALF at 8 d pi. (B) Inflammatory cell counts a...
<p>Cytokine levels and cytokine secreting cell responses were determined before (A-C) or after chall...
<p>(A-F) Lung tissues collected from individual mice (n = 5 per groups) at 5 d.p.c. were stained wit...
(A) Lung tissues were collected at 5 days post-challenge and were stained with hematoxylin and eosin...
(A) Lung tissues were collected at 5 days post-challenge and were stained with hematoxylin and eosin...
The levels of (A) IL-4, (B) IL-5, (C) IL-6 and (D) TNF-α were determined in the lung homogenates day...
(A) Lung tissue inflammation observed on images of lung sections after H&E and PAS staining. (B) Rep...
<p>(A) The results of hematoxylin-eosin (HE) staining and immunostaining are shown. Lung tissues wer...
<p><b>(A)</b> Total histologic score is the sum of the score for each criterion (lung injury areas, ...
Lung tissues (n = 5 per group) were collected from individual mice and tissue section were stained w...
<p>Mice were immunized and challenged as described in <a href="http://www.plosone.org/article/info:d...
Cells from BALF collected at 5 days after challenge were stained with cell type-specific marker anti...
Cells from lungs collected at 5 days after challenge were stained with cell type-specific marker ant...
<p>(<b>a</b>) Lung sections obtained from mice treated as in <a href="http://www.plospathogens.org/a...
<p>(A) BAL total and differential cell counts for animals immunized with rSmVAL4 or rSmVAL4-Pro (rSm...
<p>(A) Inflammatory cell counts and classification in BALF at 8 d pi. (B) Inflammatory cell counts a...
<p>Cytokine levels and cytokine secreting cell responses were determined before (A-C) or after chall...
<p>(A-F) Lung tissues collected from individual mice (n = 5 per groups) at 5 d.p.c. were stained wit...
(A) Lung tissues were collected at 5 days post-challenge and were stained with hematoxylin and eosin...
(A) Lung tissues were collected at 5 days post-challenge and were stained with hematoxylin and eosin...
The levels of (A) IL-4, (B) IL-5, (C) IL-6 and (D) TNF-α were determined in the lung homogenates day...
(A) Lung tissue inflammation observed on images of lung sections after H&E and PAS staining. (B) Rep...
<p>(A) The results of hematoxylin-eosin (HE) staining and immunostaining are shown. Lung tissues wer...
<p><b>(A)</b> Total histologic score is the sum of the score for each criterion (lung injury areas, ...
Lung tissues (n = 5 per group) were collected from individual mice and tissue section were stained w...
<p>Mice were immunized and challenged as described in <a href="http://www.plosone.org/article/info:d...
Cells from BALF collected at 5 days after challenge were stained with cell type-specific marker anti...
Cells from lungs collected at 5 days after challenge were stained with cell type-specific marker ant...
<p>(<b>a</b>) Lung sections obtained from mice treated as in <a href="http://www.plospathogens.org/a...
<p>(A) BAL total and differential cell counts for animals immunized with rSmVAL4 or rSmVAL4-Pro (rSm...
<p>(A) Inflammatory cell counts and classification in BALF at 8 d pi. (B) Inflammatory cell counts a...
<p>Cytokine levels and cytokine secreting cell responses were determined before (A-C) or after chall...
<p>(A-F) Lung tissues collected from individual mice (n = 5 per groups) at 5 d.p.c. were stained wit...