(a) and (b) the drug concentration distribution in an ideal tumor with r0 = 0.2 cm and σ = 0.01 cm. Under constant dosing condition with different drug consumption ratios, the concentration distribution is plotted at t = 100 minutes (a) and 5 hours (b), respectively; (c) the drug concentration distribution in an ideal tumor with r0 = 0.06 cm and σ = 0.01 cm as a function of time with a large drug consumption ratio λ14 = 2.5 × 10−4 s-1 under constant dosing condition. The model parameters are set as follows: diffusion coefficient D0 = 1.3 × 10−6 cm2·s-1; chemical decomposition ratio Kmet = 2.0 × 10−4 min-1. Δt = 0.1 s; Δx ≈ 0.01 cm. The red lines are the corresponding cell density.</p
A cancer drug's effectiveness is contingent upon on its ability to reach all parts of the tumor. The...
The distribution and accumulation of nanoparticle dosage in a tumor are important in evaluating the ...
A mathematical model for describing the cancer growth dynamics in response to anticancer agents adm...
(a) and (b) are associated with the vascularized micro-environment with quick drug decay (τdecay = 6...
(a) and (b): 2D schematic illustrations of the tumor-drug models in this paper for the avascular tum...
(a) Evolution of drug concentration distribution in the x-y plane associated with z = 0. The drugs a...
(a) Growth dynamics of the tumor in vascularized homogeneous microenvironment under different period...
In all these cases, the same dosing period τcycle = 1 day, chemical decomposition parameter Kmet = 2...
(a) The growth dynamics of proliferative tumors with different drug concentrations in homogeneous mi...
<p>(A), (B), and (C) are the concentration profiles of at times weeks (short time), weeks (time a...
A model of tumor growth in a spatial environment is analyzed. The model includes proliferating and q...
In this paper we consider the effects of a single anticancer agent on the growth of a solid tumour i...
<p>(A) Snapshot of the intracellular maximal concentration , and (B) snapshot of the time integrated...
Pharmacokinetics-pharmacodynamics (PK-PD) models are standardly used to assess the availability and ...
Mathematical models used in preclinical drug discovery tend to be based on empirical growth laws.Suc...
A cancer drug's effectiveness is contingent upon on its ability to reach all parts of the tumor. The...
The distribution and accumulation of nanoparticle dosage in a tumor are important in evaluating the ...
A mathematical model for describing the cancer growth dynamics in response to anticancer agents adm...
(a) and (b) are associated with the vascularized micro-environment with quick drug decay (τdecay = 6...
(a) and (b): 2D schematic illustrations of the tumor-drug models in this paper for the avascular tum...
(a) Evolution of drug concentration distribution in the x-y plane associated with z = 0. The drugs a...
(a) Growth dynamics of the tumor in vascularized homogeneous microenvironment under different period...
In all these cases, the same dosing period τcycle = 1 day, chemical decomposition parameter Kmet = 2...
(a) The growth dynamics of proliferative tumors with different drug concentrations in homogeneous mi...
<p>(A), (B), and (C) are the concentration profiles of at times weeks (short time), weeks (time a...
A model of tumor growth in a spatial environment is analyzed. The model includes proliferating and q...
In this paper we consider the effects of a single anticancer agent on the growth of a solid tumour i...
<p>(A) Snapshot of the intracellular maximal concentration , and (B) snapshot of the time integrated...
Pharmacokinetics-pharmacodynamics (PK-PD) models are standardly used to assess the availability and ...
Mathematical models used in preclinical drug discovery tend to be based on empirical growth laws.Suc...
A cancer drug's effectiveness is contingent upon on its ability to reach all parts of the tumor. The...
The distribution and accumulation of nanoparticle dosage in a tumor are important in evaluating the ...
A mathematical model for describing the cancer growth dynamics in response to anticancer agents adm...