With its multiple regulatory partners, the conserved Protein Phosphatase type-1 (PP1) plays a central role in many functions of the biology of eukaryotic cells, including Plasmodium falciparum. Here, we characterized a protein named PfRCC-PIP, as a major partner of PfPP1. We established its direct interaction in vitro and its presence in complex with PfPP1 in the parasite. The use of Xenopus oocyte model revealed that RCC-PIP can interact with the endogenous PP1 and act in synergy with suboptimal doses of progesterone to trigger oocyte maturation, suggesting a regulatory effect on PP1. Reverse genetic studies suggested an essential role for RCC-PIP since no viable knock-out parasites could be obtained. Further, we demonstrated the capacity ...
L’un des obstacles majeurs au développement de nouveaux antipaludiques est notre connaissance limité...
International audienceProtein phosphatase 1 (PP1c) is one of the main phosphatases whose function is...
Protein phosphatase 1 (PP1) is a key enzyme for Plasmodium development. However, the detailed mechan...
With its multiple regulatory partners, the conserved Protein Phosphatase type-1 (PP1) plays a centra...
With its multiple regulatory partners, the conserved Protein Phosphatase type-1 (PP1) plays a centra...
With its multiple regulatory partners, the conserved Protein Phosphatase type-1 (PP1) plays a centra...
With its multiple regulatory partners, the conserved Protein Phosphatase type-1 (PP1) plays a centra...
With its multiple regulatory partners, the conserved Protein Phosphatase type-1 (PP1) plays a centra...
With its multiple regulatory partners, the conserved Protein Phosphatase type-1 (PP1) plays a centra...
With its multiple regulatory partners, the conserved Protein Phosphatase type-1 (PP1) plays a centra...
Malaria parasites require multiple phosphorylation and dephosphorylation steps to drive signaling pa...
International audienceMalaria parasites require multiple phosphorylation and dephosphorylation steps...
Asexual proliferation of the Plasmodium parasites that cause malaria follows a developmental program...
Abstract Background Reversible protein phosphorylation is relatively unexplored in the intracellular...
The protein called 'suppressor of the dis2 mutant (sds22+)' is an essential regulator of cell divisi...
L’un des obstacles majeurs au développement de nouveaux antipaludiques est notre connaissance limité...
International audienceProtein phosphatase 1 (PP1c) is one of the main phosphatases whose function is...
Protein phosphatase 1 (PP1) is a key enzyme for Plasmodium development. However, the detailed mechan...
With its multiple regulatory partners, the conserved Protein Phosphatase type-1 (PP1) plays a centra...
With its multiple regulatory partners, the conserved Protein Phosphatase type-1 (PP1) plays a centra...
With its multiple regulatory partners, the conserved Protein Phosphatase type-1 (PP1) plays a centra...
With its multiple regulatory partners, the conserved Protein Phosphatase type-1 (PP1) plays a centra...
With its multiple regulatory partners, the conserved Protein Phosphatase type-1 (PP1) plays a centra...
With its multiple regulatory partners, the conserved Protein Phosphatase type-1 (PP1) plays a centra...
With its multiple regulatory partners, the conserved Protein Phosphatase type-1 (PP1) plays a centra...
Malaria parasites require multiple phosphorylation and dephosphorylation steps to drive signaling pa...
International audienceMalaria parasites require multiple phosphorylation and dephosphorylation steps...
Asexual proliferation of the Plasmodium parasites that cause malaria follows a developmental program...
Abstract Background Reversible protein phosphorylation is relatively unexplored in the intracellular...
The protein called 'suppressor of the dis2 mutant (sds22+)' is an essential regulator of cell divisi...
L’un des obstacles majeurs au développement de nouveaux antipaludiques est notre connaissance limité...
International audienceProtein phosphatase 1 (PP1c) is one of the main phosphatases whose function is...
Protein phosphatase 1 (PP1) is a key enzyme for Plasmodium development. However, the detailed mechan...