Relationship of the CRP, PCT, and P-SEP concentrations with the SOFA scores.

There is a significant association between the PCT levels and the SOFA scores before treatment, but not between CRP and SOFA scores (A, B). The SOFA scores have the strongest positive correlation with the P-SEP concentrations (r = 0.89, p < 0.001, C). The increase from baseline in the SOFA scores has the strongest positive correlation with the P-SEP levels, unlike the others (D–F). Spearman’s rank correlation coefficient was used to examine the relationship between the values and SOFA scores. CRP: C-reactive protein, PCT: procalcitonin, P-SEP: presepsin, SOFA score: Sequential Organ Failure Assessment score, Ln: natural logarithm. *SOFA scores were defined based on laboratory data on day 1 in 9 patients and on day 2 in 2 patients (#8 and #11).