Table S2. MD simulation results of the first populated site of the C19 compound in the KRAS4b-PDEδ complex. (DOC 40 kb
Additional file 1: Figure S1. Design of a novel PKA inhibitor, MHY4571, from the structure of the we...
Figure S4. The autophagy inhibitor chloroquine blocks KRA-533-induced autophagy in NSCLC cells. A549...
Figure 1. Phase contrast microscope images of C1 and C2 organoids. Figure 2. Ingenuity Pathway Analy...
Figure S1. Conformation 1 of the KRAS4b-PDEδ-C19 complex. (A) Conformation 1 of the KRAS4b-PDEδ-C19 ...
Table S3. Binding free energy components of protein-ligand complexes (in kcal/mol units). Binding fr...
Figure S2. C19 promotes cell death by apoptosis in a small percentage of cells of the normal colon c...
Table S2. The time-dependence of RMSD and RG by D14 and C22 compounds that target wild-type and muta...
Figure S3. TUNEL staining of xenograft tumors. (A) Apoptotic cells appear green and nuclei were stai...
Table S3. Summary of histopathological analysis and in vivo evaluation by the D14 and C22 compounds ...
Table S1. Potential candidates to stabilize the KRas4B-PDE6δ complex. Results obtained from the virt...
Figure S2. KRA-533 induces caspase 3 activation and reduces mitochondrial membrane potential in NSCL...
Figure S9. Potency of KRA-533 in genetically engineered LSL-KRASG12D LKB1fl/fl (KL) mice. (A) and (B...
Figure S1. KRA-533 inhibits proliferation of NSCLC cells. (A) A549, H157, Calu-1 and H292 cells were...
Table S1. KEGG pathway analysis for genes upregulated in ID8-KRAS-3D cells compared to ID8-3D cells....
Principal component analysis (PCA) suggests that the small molecule KI-7 will induce the EC differen...
Additional file 1: Figure S1. Design of a novel PKA inhibitor, MHY4571, from the structure of the we...
Figure S4. The autophagy inhibitor chloroquine blocks KRA-533-induced autophagy in NSCLC cells. A549...
Figure 1. Phase contrast microscope images of C1 and C2 organoids. Figure 2. Ingenuity Pathway Analy...
Figure S1. Conformation 1 of the KRAS4b-PDEδ-C19 complex. (A) Conformation 1 of the KRAS4b-PDEδ-C19 ...
Table S3. Binding free energy components of protein-ligand complexes (in kcal/mol units). Binding fr...
Figure S2. C19 promotes cell death by apoptosis in a small percentage of cells of the normal colon c...
Table S2. The time-dependence of RMSD and RG by D14 and C22 compounds that target wild-type and muta...
Figure S3. TUNEL staining of xenograft tumors. (A) Apoptotic cells appear green and nuclei were stai...
Table S3. Summary of histopathological analysis and in vivo evaluation by the D14 and C22 compounds ...
Table S1. Potential candidates to stabilize the KRas4B-PDE6δ complex. Results obtained from the virt...
Figure S2. KRA-533 induces caspase 3 activation and reduces mitochondrial membrane potential in NSCL...
Figure S9. Potency of KRA-533 in genetically engineered LSL-KRASG12D LKB1fl/fl (KL) mice. (A) and (B...
Figure S1. KRA-533 inhibits proliferation of NSCLC cells. (A) A549, H157, Calu-1 and H292 cells were...
Table S1. KEGG pathway analysis for genes upregulated in ID8-KRAS-3D cells compared to ID8-3D cells....
Principal component analysis (PCA) suggests that the small molecule KI-7 will induce the EC differen...
Additional file 1: Figure S1. Design of a novel PKA inhibitor, MHY4571, from the structure of the we...
Figure S4. The autophagy inhibitor chloroquine blocks KRA-533-induced autophagy in NSCLC cells. A549...
Figure 1. Phase contrast microscope images of C1 and C2 organoids. Figure 2. Ingenuity Pathway Analy...