<i>A-</i>type potassium channels suppressed the dendritic spread of signaling microdomains in all species of the signaling network, even when the synapse receiving a plasticity-inducing stimulus was localized on a spine.

(A) Kymographs depicting the spatiotemporal spread of microdomains along the biochemical signaling cascade in response to TBS with the spine/shaft = 0 mS/cm2 (left) and = 1000 mS/cm2 (right). (B) Peak voltage, Vmax (top), maximum value of cytosolic calcium concentration, (middle) and maximum value of phosphorylated CaMKII concentration, [pCaMKII]max (bottom) as recorded in response to TBS at the spine-head (left), spine-neck (middle) and dendritic shaft (right) for different spine/shaft levels. (C) Peak value (top panels) and area under the curve, AUC (bottom panels) of (left) and [pCaMKII]max (right) plotted against for spine head (red), spine-neck (blue) and oblique shaft (black). All channel conductances were assigned to their default values (Fig 1). Details of parametric values (of active and passive properties in the oblique dendrite shown in Fig 2A) employed for simulations presented in this figure are provided in S1 Table.