3D renderings of ventricle enlargement in monocyte-depleted vs. sham-depleted mice after traumatic brain injury.

A) Shown in RED is the extent of traumatically injured tissue at post injury days 1, 7, and 14. Shown in light BLUE is the ventricle size. There is a progressive increase in ventricle size and decrease in injured tissue indicating loss of brain tissue and replacement with cerebrospinal fluid over the course of injury. At 14 days post-TBI the increase in ventricle size between B) monocyte-depleted mice (5.3 ± 0.9mm3) and C) sham-depleted mice (13.2 ± 3.1mm3) is markedly attenuated (p = 0.02) indicating preservation of the injured neuronal matter.