Nine significant differentially expressed subnetworks between primary tumors and metastatic lesions in endometrial cancer.

Subnetworks identified from PPI and gene-gene expression correlations in primary tumors; PTME (A-C), and metastases; MEPT and MEME (D-I) are shown, respectively. Subnetworks marked as circular nodes are enriched with up-regulated genes in primary endometrial carcinomas while triangular nodes indicate enrichment of up-regulated genes in metastatic lesions. In each subnetwork, a node represents a gene and its corresponding protein, and a link between two nodes represents Topological Overlap Measure (TOM)-based connectivity. The thickness of a link shows levels of TOM-based connectivity and a red colored link represents two nodes with a PPI between them. For each node, the colors show fold change of expression between primary tumors and metastatic lesions. Red color indicates higher gene expression in primary endometrial carcinomas and green color indicates higher gene expression in metastatic lesions. Leading edge nodes are illustrated with solid lines, while non-leading edge nodes have dashed lines. The nine subnetworks are shown with colored labels according to a starting sample group of gene-gene correlations and enrichment of up-regulated genes in a sample group: PTME in red; MEPT in blue; and MEME in green.