Abundance of SMAD3, SMAD2 and SNAIL within human CKD lesions.

Maja Životić (790841)
Björn Tampe (790842)
Gerhard Müller (2507365)
Claudia Müller (19978)
Aleksandar Lipkovski (5921300)
Xingbo Xu (212588)
Gunsmaa Nyamsuren (342747)
Michael Zeisberg (72696)
Jasmina Marković-Lipkovski (559579)

Open link

Publication date

November 2018

DOI

10.1371/journal.pone.0206786.g007

Publisher

Public Library of Science (PLoS)

Abstract

(A,B) Representative photomicrographs of human kidney specimens immunolabeled for SMAD3 in collecting ducts in renal medulla (200x, A), SMAD3 in distal tubules in renal cortex (200x, B). (C-H) Representative photomicrographs of interstitial fibrosis and tubular atrophy with global glomerulosclerosis in a patient with end-stage kidney disease stained for PAS (400x, C), SMAD3 in collecting ducts in renal cortex and absence of SMAD3 in atrophic tubuli (400x, D), SMAD2 in atrophic tubules surrounded with interstitial fibrosis (400x, E), SNAIL in atrophic tubules surrounded with interstitial fibrosis (400x, F), in podocytes in patient with nephrotic range proteinuria (400x, G) and in podocytes in a patient with sub-nephrotic proteinuria (400x, H...