Poly I:C immunotherapy is ineffective in hyperuricaemic PLT2 mice.

C57BL/6 (WT) and PLT2 mice were challenged with B16 tumor cells and given peri-tumoral injections of PBS or Poly I:C on days 9, 11, 13 and 15. (A) Tumor growth. Graph shows mean tumor size±SEM in groups of 15 mice pooled from three independent experiments. Statistical analysis was by 2-way ANOVA with Tukey’s correction, the p values shown in Figure refer to the comparison between WT Poly I:C and PLT2 Poly I:C. ***pB) Kaplan-Meier survival curves. Data are pooled from four independent experiments, n = 20 mice/group. Statistical analysis was by log-rank test with Bonferroni correction; *p<0.05, **p<0.01.