Safer Synthesis of (Diacetoxyiodo)arenes Using Sodium Hypochlorite Pentahydrate
- Ayumi Watanabe (1941811)
- Kazunori Miyamoto (1466113)
- Tomohide Okada (4623805)
- Tomotake Asawa (5945780)
- Masanobu Uchiyama (1466110)
Publication date
November 2018
DOI Publisher
American Chemical Society (ACS)Abstract
A practical method for the preparation of (diacetoxyiodo)arene ArI(OAc)2 is described. The use of commercially available sodium hypochlorite pentahydrate (NaClO·5H2O) enabled safe, rapid, and inexpensive oxidation of iodoarenes with electron-withdrawing and -donating substituents. The method allows tandem divergent access to synthetically useful organo-λ3-iodanes such as hydroxyl(tosyloxy)iodobenzene, iodosylbenzene, iodonium ylide, etc
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