Additional file 1: of Sexually dimorphic metabolic responses mediated by CRF2 receptor during nutritional stress in mice

Crhr2+/− male mice gain more body mass. Line graphs showing weekly change in body mass in male (n = 9/group) and female (n = 9/group) Crhr2+/− mice on chow and HFD. Data is presented as change in body mass per week compared to baseline. (a) Crhr2+/− male mice gained ~ 18.6% body mass on chow and ~ 45% on HFD. (b): Bar graphs showing percent (%) change in body mass for chow- or HFD-fed mice. HFD-fed Crhr2+/− male mice gained ~ 26% more body mass than chow-fed Crhr2+/− mice. (c) Crhr2+/− female mice gained ~ 8.8% body mass on chow and nearly ~ 50.5% on HFD. (d) HFD-fed Crhr2+/− female mice gained ~ 41.7% more body mass than chow-fed Crhr2+/− mice. 3-Way ANOVA and post hoc Tukey’s multiple comparisons as described in main text and figure legends. (DOCX 224 kb