Additional file 13: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Additional file 6: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a-h) UCSC Genome Browser view for (a) KLK10, (b) MADH2/SMAD2, (c) AKT2, (d) DNMT1, (e) DYRK1B, (f) ...

Additional file 3: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a) Metaphase counts of DLD-1 cells consistently show pseudo-diploid chromosome numbers of 44–46. Sc...

Additional file 4: of HDAC2 depletion promotes osteosarcoma’s stemness both in vitro and in vivo: a study on a putative new target for CSCs directed therapy

Marcella Noce (6039740)
Francesca Paino (215309)
Luigi Mele (6039743)
Gianpaolo Papaccio (30293)
Tarik Regad (6039746)
Angela Lombardi (782207)
Federica Papaccio (5618651)
Vincenzo Desiderio (353479)
Virginia Tirino (215281)

December 2018

Figure S2. Evaluation of CD133 marker on Saos2 and MG63 cell lines after VPA and DAC treatment. Flow...

Additional file 12: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S8. 3D distribution of LaminA/C (green) in aged HSCs. Nucleus is stained with DAPI (blue). (AV...

Additional file 11: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S7. 3D distribution of LaminA/C (green) in young HSCs. Nucleus is stained with DAPI (blue). (A...

Additional file 9: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S5. 3D distribution of H4K16ac (green) and chromosome 11 (red) in aged HSCs. Nucleus is staine...

Additional file 7: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S3. 3D distribution of chromosome 11 (red) in CASIN-treated aged HSCs. Nucleus is stained with...

Additional file 8: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S4. 3D distribution of H4K16ac (green) and chromosome 11 (red) in young HSCs. Nucleus is stain...

Additional file 6: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S2. 3D distribution of chromosome 11 (red) in aged HSCs. Nucleus is stained with DAPI (blue). ...

Additional file 5: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S1. 3D distribution of chromosome 11 (red) in young HSCs. Nucleus is stained with DAPI (blue)....

Additional file 3: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Table S2. RNA-seq expression profile of all genes analyzed (total genes 22548) in young, aged, and a...

Additional file 2: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Table S1. 118 common genes that presented with differential binding of H4K16ac in young and aged CAS...

Additional file 4: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Table S3. Comparisons with three different stringency levels (no false discovery rate adjustment (no...

Additional file 1: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a) Immunostaining for Emerin (green), Lamin A/C (red) in untreated, siLamin A/C and siLamin A/C scr...

Additional file 7: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a) UCSC Genome Browser view for BCL2L12, depicting the Lamina Associated Domains (NKI LAD track). (...

Additional file 6: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a-h) UCSC Genome Browser view for (a) KLK10, (b) MADH2/SMAD2, (c) AKT2, (d) DNMT1, (e) DYRK1B, (f) ...

Additional file 3: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a) Metaphase counts of DLD-1 cells consistently show pseudo-diploid chromosome numbers of 44–46. Sc...

Additional file 4: of HDAC2 depletion promotes osteosarcoma’s stemness both in vitro and in vivo: a study on a putative new target for CSCs directed therapy

Marcella Noce (6039740)
Francesca Paino (215309)
Luigi Mele (6039743)
Gianpaolo Papaccio (30293)
Tarik Regad (6039746)
Angela Lombardi (782207)
Federica Papaccio (5618651)
Vincenzo Desiderio (353479)
Virginia Tirino (215281)

December 2018

Figure S2. Evaluation of CD133 marker on Saos2 and MG63 cell lines after VPA and DAC treatment. Flow...

Additional file 12: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S8. 3D distribution of LaminA/C (green) in aged HSCs. Nucleus is stained with DAPI (blue). (AV...

Additional file 11: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S7. 3D distribution of LaminA/C (green) in young HSCs. Nucleus is stained with DAPI (blue). (A...

Additional file 9: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S5. 3D distribution of H4K16ac (green) and chromosome 11 (red) in aged HSCs. Nucleus is staine...

Additional file 7: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S3. 3D distribution of chromosome 11 (red) in CASIN-treated aged HSCs. Nucleus is stained with...

Additional file 8: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S4. 3D distribution of H4K16ac (green) and chromosome 11 (red) in young HSCs. Nucleus is stain...

Additional file 6: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S2. 3D distribution of chromosome 11 (red) in aged HSCs. Nucleus is stained with DAPI (blue). ...

Additional file 5: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S1. 3D distribution of chromosome 11 (red) in young HSCs. Nucleus is stained with DAPI (blue)....

Additional file 3: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Table S2. RNA-seq expression profile of all genes analyzed (total genes 22548) in young, aged, and a...

Additional file 2: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Table S1. 118 common genes that presented with differential binding of H4K16ac in young and aged CAS...

Additional file 4: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Table S3. Comparisons with three different stringency levels (no false discovery rate adjustment (no...

Additional file 1: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a) Immunostaining for Emerin (green), Lamin A/C (red) in untreated, siLamin A/C and siLamin A/C scr...

Additional file 7: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a) UCSC Genome Browser view for BCL2L12, depicting the Lamina Associated Domains (NKI LAD track). (...

Additional file 6: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a-h) UCSC Genome Browser view for (a) KLK10, (b) MADH2/SMAD2, (c) AKT2, (d) DNMT1, (e) DYRK1B, (f) ...

Additional file 3: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a) Metaphase counts of DLD-1 cells consistently show pseudo-diploid chromosome numbers of 44–46. Sc...

Additional file 4: of HDAC2 depletion promotes osteosarcoma’s stemness both in vitro and in vivo: a study on a putative new target for CSCs directed therapy

Marcella Noce (6039740)
Francesca Paino (215309)
Luigi Mele (6039743)
Gianpaolo Papaccio (30293)
Tarik Regad (6039746)
Angela Lombardi (782207)
Federica Papaccio (5618651)
Vincenzo Desiderio (353479)
Virginia Tirino (215281)

December 2018

Figure S2. Evaluation of CD133 marker on Saos2 and MG63 cell lines after VPA and DAC treatment. Flow...

Additional file 13: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Abstract

Extracted data

Additional file 13: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Abstract

Extracted data

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