Additional file 12: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Additional file 1: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a) Immunostaining for Emerin (green), Lamin A/C (red) in untreated, siLamin A/C and siLamin A/C scr...

Additional file 6: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a-h) UCSC Genome Browser view for (a) KLK10, (b) MADH2/SMAD2, (c) AKT2, (d) DNMT1, (e) DYRK1B, (f) ...

Aging Stem Cells: Transcriptome Meets Epigenome Meets Methylome

Tümpel, Stefan
Rudolph, K. Lenhard

May 2014

Aging is associated with impairments in hematopoietic stem cell (HSC) function and an increased risk...

Additional file 11: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S7. 3D distribution of LaminA/C (green) in young HSCs. Nucleus is stained with DAPI (blue). (A...

Additional file 13: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S9. 3D distribution of LaminA/C (green) in CASIN-treated aged HSCs. Nucleus is stained with DA...

Additional file 9: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S5. 3D distribution of H4K16ac (green) and chromosome 11 (red) in aged HSCs. Nucleus is staine...

Additional file 8: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S4. 3D distribution of H4K16ac (green) and chromosome 11 (red) in young HSCs. Nucleus is stain...

Additional file 6: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S2. 3D distribution of chromosome 11 (red) in aged HSCs. Nucleus is stained with DAPI (blue). ...

Additional file 5: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S1. 3D distribution of chromosome 11 (red) in young HSCs. Nucleus is stained with DAPI (blue)....

Additional file 7: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S3. 3D distribution of chromosome 11 (red) in CASIN-treated aged HSCs. Nucleus is stained with...

Additional file 2: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Table S1. 118 common genes that presented with differential binding of H4K16ac in young and aged CAS...

Additional file 3: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Table S2. RNA-seq expression profile of all genes analyzed (total genes 22548) in young, aged, and a...

Additional file 4: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Table S3. Comparisons with three different stringency levels (no false discovery rate adjustment (no...

LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan
Novella Guidi
Katharina Senger
Thomas Liehr
Karin Soller
Gina Marka
Angelika Vollmer
Yolanda Markaki
Heinrich Leonhardt
Christian Buske
Daniel B. Lipka
Christoph Plass
Yi Zheng
Medhanie A. Mulaw
Hartmut Geiger
Maria Carolina Florian

November 2018

Abstract Background The decline of hematopoietic stem cell (HSC) function upon aging contributes to ...

Additional file 7: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a) UCSC Genome Browser view for BCL2L12, depicting the Lamina Associated Domains (NKI LAD track). (...

Additional file 1: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a) Immunostaining for Emerin (green), Lamin A/C (red) in untreated, siLamin A/C and siLamin A/C scr...

Additional file 6: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a-h) UCSC Genome Browser view for (a) KLK10, (b) MADH2/SMAD2, (c) AKT2, (d) DNMT1, (e) DYRK1B, (f) ...

Aging Stem Cells: Transcriptome Meets Epigenome Meets Methylome

Tümpel, Stefan
Rudolph, K. Lenhard

May 2014

Aging is associated with impairments in hematopoietic stem cell (HSC) function and an increased risk...

Additional file 11: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S7. 3D distribution of LaminA/C (green) in young HSCs. Nucleus is stained with DAPI (blue). (A...

Additional file 13: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S9. 3D distribution of LaminA/C (green) in CASIN-treated aged HSCs. Nucleus is stained with DA...

Additional file 9: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S5. 3D distribution of H4K16ac (green) and chromosome 11 (red) in aged HSCs. Nucleus is staine...

Additional file 8: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S4. 3D distribution of H4K16ac (green) and chromosome 11 (red) in young HSCs. Nucleus is stain...

Additional file 6: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S2. 3D distribution of chromosome 11 (red) in aged HSCs. Nucleus is stained with DAPI (blue). ...

Additional file 5: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S1. 3D distribution of chromosome 11 (red) in young HSCs. Nucleus is stained with DAPI (blue)....

Additional file 7: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S3. 3D distribution of chromosome 11 (red) in CASIN-treated aged HSCs. Nucleus is stained with...

Additional file 2: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Table S1. 118 common genes that presented with differential binding of H4K16ac in young and aged CAS...

Additional file 3: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Table S2. RNA-seq expression profile of all genes analyzed (total genes 22548) in young, aged, and a...

Additional file 4: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Table S3. Comparisons with three different stringency levels (no false discovery rate adjustment (no...

LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan
Novella Guidi
Katharina Senger
Thomas Liehr
Karin Soller
Gina Marka
Angelika Vollmer
Yolanda Markaki
Heinrich Leonhardt
Christian Buske
Daniel B. Lipka
Christoph Plass
Yi Zheng
Medhanie A. Mulaw
Hartmut Geiger
Maria Carolina Florian

November 2018

Abstract Background The decline of hematopoietic stem cell (HSC) function upon aging contributes to ...

Additional file 7: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a) UCSC Genome Browser view for BCL2L12, depicting the Lamina Associated Domains (NKI LAD track). (...

Additional file 1: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a) Immunostaining for Emerin (green), Lamin A/C (red) in untreated, siLamin A/C and siLamin A/C scr...

Additional file 6: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a-h) UCSC Genome Browser view for (a) KLK10, (b) MADH2/SMAD2, (c) AKT2, (d) DNMT1, (e) DYRK1B, (f) ...

Aging Stem Cells: Transcriptome Meets Epigenome Meets Methylome

Tümpel, Stefan
Rudolph, K. Lenhard

May 2014

Aging is associated with impairments in hematopoietic stem cell (HSC) function and an increased risk...

Additional file 12: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Abstract

Extracted data

Additional file 12: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Abstract

Extracted data

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