Additional file 6: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Additional file 6: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a-h) UCSC Genome Browser view for (a) KLK10, (b) MADH2/SMAD2, (c) AKT2, (d) DNMT1, (e) DYRK1B, (f) ...

Additional file 2: of Tracking of epigenetic changes during hematopoietic differentiation of induced pluripotent stem cells

Olivia Cypris (6296426)
Joana Frobel (3509495)
Shivam Rai (6296429)
Julia Franzen (5118830)
Stephanie Sontag (416324)
Roman Goetzke (6296438)
Marcelo Szymanski de Toledo (6296444)
Martin Zenke (162192)
Wolfgang Wagner (47115)

February 2019

Figure S2. Enrichment of hyper- and hypomethylated CpG sites in iPSC-derived HPCs. Changes in DNA me...

Additional file 7: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a) UCSC Genome Browser view for BCL2L12, depicting the Lamina Associated Domains (NKI LAD track). (...

Additional file 5: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S1. 3D distribution of chromosome 11 (red) in young HSCs. Nucleus is stained with DAPI (blue)....

Additional file 7: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S3. 3D distribution of chromosome 11 (red) in CASIN-treated aged HSCs. Nucleus is stained with...

Additional file 9: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S5. 3D distribution of H4K16ac (green) and chromosome 11 (red) in aged HSCs. Nucleus is staine...

Additional file 8: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S4. 3D distribution of H4K16ac (green) and chromosome 11 (red) in young HSCs. Nucleus is stain...

Additional file 11: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S7. 3D distribution of LaminA/C (green) in young HSCs. Nucleus is stained with DAPI (blue). (A...

Additional file 12: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S8. 3D distribution of LaminA/C (green) in aged HSCs. Nucleus is stained with DAPI (blue). (AV...

Additional file 13: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S9. 3D distribution of LaminA/C (green) in CASIN-treated aged HSCs. Nucleus is stained with DA...

Additional file 3: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Table S2. RNA-seq expression profile of all genes analyzed (total genes 22548) in young, aged, and a...

Additional file 2: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Table S1. 118 common genes that presented with differential binding of H4K16ac in young and aged CAS...

Additional file 4: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Table S3. Comparisons with three different stringency levels (no false discovery rate adjustment (no...

LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Grigoryan, Ani
Guidi, Novella
Senger, Katharina
Liehr, Thomas
Soller, Karin
Marka, Gina
Vollmer, Angelika
Markaki, Yolanda
Leonhardt, Heinrich
Buske, Christian
Lipka, Daniel B.
Plass, Christoph
Zheng, Yi
Mulaw, Medhanie A.
Geiger, Hartmut
Florian, Maria Carolina

January 2018

Background: The decline of hematopoietic stem cell (HSC) function upon aging contributes to aging-as...

Additional file 6: of Tracking of epigenetic changes during hematopoietic differentiation of induced pluripotent stem cells

Olivia Cypris (6296426)
Joana Frobel (3509495)
Shivam Rai (6296429)
Julia Franzen (5118830)
Stephanie Sontag (416324)
Roman Goetzke (6296438)
Marcelo Szymanski de Toledo (6296444)
Martin Zenke (162192)
Wolfgang Wagner (47115)

February 2019

Figure S4. Differentiation of iPSCs toward MSCs. (a) Phase contrast images of iPSCs and in the cours...

Additional file 6: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a-h) UCSC Genome Browser view for (a) KLK10, (b) MADH2/SMAD2, (c) AKT2, (d) DNMT1, (e) DYRK1B, (f) ...

Additional file 2: of Tracking of epigenetic changes during hematopoietic differentiation of induced pluripotent stem cells

Olivia Cypris (6296426)
Joana Frobel (3509495)
Shivam Rai (6296429)
Julia Franzen (5118830)
Stephanie Sontag (416324)
Roman Goetzke (6296438)
Marcelo Szymanski de Toledo (6296444)
Martin Zenke (162192)
Wolfgang Wagner (47115)

February 2019

Figure S2. Enrichment of hyper- and hypomethylated CpG sites in iPSC-derived HPCs. Changes in DNA me...

Additional file 7: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a) UCSC Genome Browser view for BCL2L12, depicting the Lamina Associated Domains (NKI LAD track). (...

Additional file 5: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S1. 3D distribution of chromosome 11 (red) in young HSCs. Nucleus is stained with DAPI (blue)....

Additional file 7: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S3. 3D distribution of chromosome 11 (red) in CASIN-treated aged HSCs. Nucleus is stained with...

Additional file 9: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S5. 3D distribution of H4K16ac (green) and chromosome 11 (red) in aged HSCs. Nucleus is staine...

Additional file 8: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S4. 3D distribution of H4K16ac (green) and chromosome 11 (red) in young HSCs. Nucleus is stain...

Additional file 11: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S7. 3D distribution of LaminA/C (green) in young HSCs. Nucleus is stained with DAPI (blue). (A...

Additional file 12: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S8. 3D distribution of LaminA/C (green) in aged HSCs. Nucleus is stained with DAPI (blue). (AV...

Additional file 13: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Video S9. 3D distribution of LaminA/C (green) in CASIN-treated aged HSCs. Nucleus is stained with DA...

Additional file 3: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Table S2. RNA-seq expression profile of all genes analyzed (total genes 22548) in young, aged, and a...

Additional file 2: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Table S1. 118 common genes that presented with differential binding of H4K16ac in young and aged CAS...

Additional file 4: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Ani Grigoryan (5944232)
Novella Guidi (5944235)
Katharina Senger (144682)
Thomas Liehr (484)
Karin Soller (5774207)
Gina Marka (5774204)
Angelika Vollmer (3953435)
Yolanda Markaki (3502454)
Heinrich Leonhardt (18589)
Christian Buske (3722989)
Daniel Lipka (3512798)
Christoph Plass (14626)
Yi Zheng (113896)
Medhanie Mulaw (5944241)
Hartmut Geiger (144685)
Maria Florian (629873)

November 2018

Table S3. Comparisons with three different stringency levels (no false discovery rate adjustment (no...

LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Grigoryan, Ani
Guidi, Novella
Senger, Katharina
Liehr, Thomas
Soller, Karin
Marka, Gina
Vollmer, Angelika
Markaki, Yolanda
Leonhardt, Heinrich
Buske, Christian
Lipka, Daniel B.
Plass, Christoph
Zheng, Yi
Mulaw, Medhanie A.
Geiger, Hartmut
Florian, Maria Carolina

January 2018

Background: The decline of hematopoietic stem cell (HSC) function upon aging contributes to aging-as...

Additional file 6: of Tracking of epigenetic changes during hematopoietic differentiation of induced pluripotent stem cells

Olivia Cypris (6296426)
Joana Frobel (3509495)
Shivam Rai (6296429)
Julia Franzen (5118830)
Stephanie Sontag (416324)
Roman Goetzke (6296438)
Marcelo Szymanski de Toledo (6296444)
Martin Zenke (162192)
Wolfgang Wagner (47115)

February 2019

Figure S4. Differentiation of iPSCs toward MSCs. (a) Phase contrast images of iPSCs and in the cours...

Additional file 6: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a-h) UCSC Genome Browser view for (a) KLK10, (b) MADH2/SMAD2, (c) AKT2, (d) DNMT1, (e) DYRK1B, (f) ...

Additional file 2: of Tracking of epigenetic changes during hematopoietic differentiation of induced pluripotent stem cells

Olivia Cypris (6296426)
Joana Frobel (3509495)
Shivam Rai (6296429)
Julia Franzen (5118830)
Stephanie Sontag (416324)
Roman Goetzke (6296438)
Marcelo Szymanski de Toledo (6296444)
Martin Zenke (162192)
Wolfgang Wagner (47115)

February 2019

Figure S2. Enrichment of hyper- and hypomethylated CpG sites in iPSC-derived HPCs. Changes in DNA me...

Additional file 7: of Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Devika Ranade (6726710)
Roopali Pradhan (6726713)
Muhunden Jayakrishnan (6726716)
Sushmitha Hegde (6726719)
Kundan Sengupta (379275)

May 2019

(a) UCSC Genome Browser view for BCL2L12, depicting the Lamina Associated Domains (NKI LAD track). (...

Additional file 6: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Abstract

Extracted data

Additional file 6: of LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Abstract

Extracted data

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