Figure S1. Reduced fiber diameter in GAAKO animals. A. Fiber diameter frequency distribution plot of WT(FVB) and Gaa−/−(FVB) at 15 weeks of age. B. WT(Bl6) and GAAKO(Bl6) at 3 months of age showing reduced fiber diameter in Gaa−/− (Bl6). These data suggest muscle atrophy is observed in GAA-deficient animals on both FVB/N and C57/Bl6 backgrounds. (PDF 122 kb
Figure S2. Fiber types are not changed in ΔKlotho mice. (A) Representative immunofluorescence staini...
Examples of muscle fibers that show evidence of recent muscle regeneration. The arrows point to cent...
Example of MyoD (red, arrow) and Myogenin (green, arrow) immunofluorescent stainings. These markers ...
Figure S2. Modest muscle regeneration in Gaa−/−(Bl6) animals. A.eMyHC staining of QF sections from W...
Figure S3. Satellite cell numbers are increased in Gaa−/− TA muscle. The number of Pax7-positive cel...
Figure S9. Efficient regeneration of GAAKO-muscle after cardiotoxin-induced injury in GAA-deficient ...
Figure S5. Satellite cell numbers are increased in Gaa−/−(Bl6) muscle. A. Satellite cells were detec...
Figure S6. Detection of proliferating satellite cells in GAA-deficient limb muscle. Representative i...
Figure S4. Identification of Pax7-positive satellite cells by flow cytometry. A. Representative dot ...
Average muscle fiber cross sectional area (CSA) is shifted rightward with a consistent distribution ...
Unchanged satellite cell proliferation in Pompe disease. Cryosections from Pompe muscle biopsies wer...
Figure S2. Young adult dKO mice show limited signs of muscle disease. H&E-stained sections of uninju...
Figure S1. ΔKlotho mice display signs of sarcopenia. (A) Immunofluorescence of cross-sections of TA ...
Figure S1. TEM of GRAF1 tibialis anterior muscle. TEM (Ă2500 magnification) reveals T-tubule abnorm...
Hypertrophic response after synergist ablation overload of the plantaris for 10 days (OV) in young v...
Figure S2. Fiber types are not changed in ΔKlotho mice. (A) Representative immunofluorescence staini...
Examples of muscle fibers that show evidence of recent muscle regeneration. The arrows point to cent...
Example of MyoD (red, arrow) and Myogenin (green, arrow) immunofluorescent stainings. These markers ...
Figure S2. Modest muscle regeneration in Gaa−/−(Bl6) animals. A.eMyHC staining of QF sections from W...
Figure S3. Satellite cell numbers are increased in Gaa−/− TA muscle. The number of Pax7-positive cel...
Figure S9. Efficient regeneration of GAAKO-muscle after cardiotoxin-induced injury in GAA-deficient ...
Figure S5. Satellite cell numbers are increased in Gaa−/−(Bl6) muscle. A. Satellite cells were detec...
Figure S6. Detection of proliferating satellite cells in GAA-deficient limb muscle. Representative i...
Figure S4. Identification of Pax7-positive satellite cells by flow cytometry. A. Representative dot ...
Average muscle fiber cross sectional area (CSA) is shifted rightward with a consistent distribution ...
Unchanged satellite cell proliferation in Pompe disease. Cryosections from Pompe muscle biopsies wer...
Figure S2. Young adult dKO mice show limited signs of muscle disease. H&E-stained sections of uninju...
Figure S1. ΔKlotho mice display signs of sarcopenia. (A) Immunofluorescence of cross-sections of TA ...
Figure S1. TEM of GRAF1 tibialis anterior muscle. TEM (Ă2500 magnification) reveals T-tubule abnorm...
Hypertrophic response after synergist ablation overload of the plantaris for 10 days (OV) in young v...
Figure S2. Fiber types are not changed in ΔKlotho mice. (A) Representative immunofluorescence staini...
Examples of muscle fibers that show evidence of recent muscle regeneration. The arrows point to cent...
Example of MyoD (red, arrow) and Myogenin (green, arrow) immunofluorescent stainings. These markers ...