Tarin reduces cytotoxic effects in CY-immunosuppressed mice.

(A) Leukocytes number in peripheral mice blood treated with: CY–CY-immunosuppressed mice; CY + Tarin–CY-immunosuppressed mice treated with 200 μg tarin on day 0, 2 and 5; Tarin–mice treated with 200 μg tarin on days 0, 2, and 5; and Control–animals inoculated with saline. Blood samples were collected on days 0, 2, 5, and 7. ***pvs Control comparison on day 2, and CY + Tarin vs CY on day 5. *p(B) Occurrence of micronuclei in BM erythroid cells from: CY300—mice immunosuppressed with 300 mg/kg CY; CY50—mice immunosuppressed with 50 mg/kg; CY300 + Tarin—mice immunosuppressed with 300 mg/kg and treated with 200 μg tarin and CY50 + Tarin—mice immunosuppressed with 50 mg/kg and treated with 200 μg tarin. ***ppCY50 to CY50+Tarin, and #pCY300 to CY300+Tarin.