Systematically benchmarking peptide-MHC binding predictors: From synthetic to naturally processed epitopes - Fig 7

Reliability of predicting absolute affinities of strong binding MHC Class I and II epitopes for (a) NetMHC4, (b) mhcflurry-class I, (c) nn_align, and (d) mhcflurry-class II. Measurement and prediction values were represented as 1-log10(IC50)/log10(50000 nM) and were light-colored based on 2-D data density. Grey dotted lines mark 50 nM threshold (y = 0.638) and grey dashed lines mark 500 nM (y = 0.426) threshold. Red lines show the linear regression of the data. FNr(50 nM) indicates the false negative rate of classifying strong binders.