Developmental activation of the AHR down-regulates BMDC genes involved in pathways critical for DC function.

Mature BMDC were generated from adult offspring (8–10 weeks old) of B6 dams treated with vehicle control or TCDD. The volcano plot shows -log10(p-value) vs. log2(fold change) of genes assayed by PCR array in LPS stimulated BMDC. Log2(fold change) calculated relative to LPS stimulated BMDCs from offspring developmentally exposed to vehicle. The horizontal dotted line indicates significance at -log10(0.05). Genes were considered significantly different when p ≤ 0.05. All offspring within a group are from a separate dam (n = 6 mice per group). Underlying data can be found in S1 Data.