Additional file 1: of Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system

Additional file 1: of NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis

Carlo Marchetti (5594576)
Benjamin Swartzwelter (5594579)
Marije Koenders (3436682)
Tania Azam (64531)
Isak Tengesdal (5594582)
Nick Powers (5594585)
Dennis de Graaf (5594588)
Charles Dinarello (5594591)
Leo Joosten (26109)

August 2018

Figure S1. Effect of oral treatment with OLT1177 in zymosan-induced arthritis. a Mean ± SEM of joint...

Additional file 1: Figure S1. of The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway

Peter Sullivan (3547517)
Xiaolai Zhou (3547520)
Adam Robins (3547526)
Daniel Paushter (3547523)
Dongsung Kim (664168)
Marcus Smolka (413545)
Fenghua Hu (217655)

May 2016

Levels of endogenous versus overexpressed C9orf72 in N2a and HEK293T cells. N2a (a) and HEK293T (b) ...

Additional file 1: of The adhesion and migration of microglia to β-amyloid (Aβ) is decreased with aging and inhibited by Nogo/NgR pathway

Yinquan Fang (3409655)
Jianing Wang (465119)
Lemeng Yao (3409652)
Chenhui Li (697156)
Jing Wang (1228470)
Yuan Liu (88411)
Xia Tao (833990)
Hao Sun (14095)
Hong Liao (124443)

July 2018

Figure S1. Congo Red dye binding assay of fAβ1–42. The aggregation of fAβ1–42 was validated by the C...

Additional file 2: of Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system

Ayaka Nakanishi (5952629)
Naoe Kaneko (5952632)
Hiroyuki Takeda (247055)
Tatsuya Sawasaki (29885)
Shinnosuke Morikawa (5952635)
Wei Zhou (24328)
Mie Kurata (551823)
Toshihiro Yamamoto (724226)
Sheikh Akbar (5952638)
Tamotsu Zako (195999)
Junya Masumoto (277060)

November 2018

Figure S2. MCC950 (A) and isoliquiritigenin (B), known NLRP3 inhibitors, did not affect the interact...

Additional file 2: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

September 2018

Figure S1. There are no oligodendrocytes contaminating the cell culture. Non-specific binding of Oli...

Additional file 5: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

November 2018

Figure S5. (A) Since there are no oligodendrocytes contaminating the cell culture, NLRP3-expression ...

Additional file 1: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

September 2018

Figure S2. Cell counting revealed 95.2% astrocytes and 4.5% microglia. Approximately 0.4% of the cel...

Additional file 3: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

September 2018

Figure S3. (A) Stimulation with Aβ1–42 led to a concentration-dependent LDH-release. For further exp...

Additional file 4: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

November 2018

Figure S4. No significant differences in cell metabolism were detected after increasing concentratio...

Additional file 3: Figure S3. of MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

Yan Zhou (6523)
Ming Lu (122276)
Ren-Hong Du (3472883)
Chen Qiao (710357)
Chun-Yi Jiang (3472892)
Ke-Zhong Zhang (3472886)
Jian-Hua Ding (3472889)
Gang Hu (132827)

April 2016

α-Synuclein activates NLRP3 inflammasome through autophagy impairment and ROS accumulation in BV2 ce...

Additional file 2: Figure S2. of MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

Yan Zhou (6523)
Ming Lu (122276)
Ren-Hong Du (3472883)
Chen Qiao (710357)
Chun-Yi Jiang (3472892)
Ke-Zhong Zhang (3472886)
Jian-Hua Ding (3472889)
Gang Hu (132827)

April 2016

Aggregated α-syn activates NLRP3 inflammasome in BV2 cells. (a) Aggregated form of WT- and A53T α-Sy...

Additional file 6: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

September 2018

Figure S6. (A) 10 μM Aβ1–42 significantly increased caspase 1 mRNA. Co-treatment with A1AT blocked t...

Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system

Ayaka Nakanishi
Naoe Kaneko
Hiroyuki Takeda
Tatsuya Sawasaki
Shinnosuke Morikawa
Wei Zhou
Mie Kurata
Toshihiro Yamamoto
Sheikh Mohammad Fazle Akbar
Tamotsu Zako
Junya Masumoto

November 2018

Abstract Background Alzheimer’s disease is a neurodegenerative disease characterized by the intersti...

MOESM1 of RIP3 dependent NLRP3 inflammasome activation is implicated in acute lung injury in mice

Jingxian Chen (3125097)
Shuang Wang (46453)
Rong Fu (180787)
Mianjing Zhou (5647943)
Tengyue Zhang (5632472)
Wenxu Pan (5647946)
Niansheng Yang (5647949)
Yuefang Huang (5647952)

August 2018

Additional file 1: Figure S1. GSK872 had no effect on NF-κB or ERK signaling in LPS/ATP stimulated T...

Additional file 3: Figure S3. of The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-β peptide

Miriam Ries (3453977)
Rodrigo Loiola (3453980)
Urvi Shah (83424)
Steve Gentleman (3453983)
Egle Solito (390951)
Magdalena Sastre (3453974)

September 2016

ImageStream quantification of 5-FAM-labelled Aβ1–42 phagocytosis by BV2 cells. Histogram showing gat...

Additional file 1: of NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis

Carlo Marchetti (5594576)
Benjamin Swartzwelter (5594579)
Marije Koenders (3436682)
Tania Azam (64531)
Isak Tengesdal (5594582)
Nick Powers (5594585)
Dennis de Graaf (5594588)
Charles Dinarello (5594591)
Leo Joosten (26109)

August 2018

Figure S1. Effect of oral treatment with OLT1177 in zymosan-induced arthritis. a Mean ± SEM of joint...

Additional file 1: Figure S1. of The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway

Peter Sullivan (3547517)
Xiaolai Zhou (3547520)
Adam Robins (3547526)
Daniel Paushter (3547523)
Dongsung Kim (664168)
Marcus Smolka (413545)
Fenghua Hu (217655)

May 2016

Levels of endogenous versus overexpressed C9orf72 in N2a and HEK293T cells. N2a (a) and HEK293T (b) ...

Additional file 1: of The adhesion and migration of microglia to β-amyloid (Aβ) is decreased with aging and inhibited by Nogo/NgR pathway

Yinquan Fang (3409655)
Jianing Wang (465119)
Lemeng Yao (3409652)
Chenhui Li (697156)
Jing Wang (1228470)
Yuan Liu (88411)
Xia Tao (833990)
Hao Sun (14095)
Hong Liao (124443)

July 2018

Figure S1. Congo Red dye binding assay of fAβ1–42. The aggregation of fAβ1–42 was validated by the C...

Additional file 2: of Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system

Ayaka Nakanishi (5952629)
Naoe Kaneko (5952632)
Hiroyuki Takeda (247055)
Tatsuya Sawasaki (29885)
Shinnosuke Morikawa (5952635)
Wei Zhou (24328)
Mie Kurata (551823)
Toshihiro Yamamoto (724226)
Sheikh Akbar (5952638)
Tamotsu Zako (195999)
Junya Masumoto (277060)

November 2018

Figure S2. MCC950 (A) and isoliquiritigenin (B), known NLRP3 inhibitors, did not affect the interact...

Additional file 2: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

September 2018

Figure S1. There are no oligodendrocytes contaminating the cell culture. Non-specific binding of Oli...

Additional file 5: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

November 2018

Figure S5. (A) Since there are no oligodendrocytes contaminating the cell culture, NLRP3-expression ...

Additional file 1: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

September 2018

Figure S2. Cell counting revealed 95.2% astrocytes and 4.5% microglia. Approximately 0.4% of the cel...

Additional file 3: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

September 2018

Figure S3. (A) Stimulation with Aβ1–42 led to a concentration-dependent LDH-release. For further exp...

Additional file 4: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

November 2018

Figure S4. No significant differences in cell metabolism were detected after increasing concentratio...

Additional file 3: Figure S3. of MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

Yan Zhou (6523)
Ming Lu (122276)
Ren-Hong Du (3472883)
Chen Qiao (710357)
Chun-Yi Jiang (3472892)
Ke-Zhong Zhang (3472886)
Jian-Hua Ding (3472889)
Gang Hu (132827)

April 2016

α-Synuclein activates NLRP3 inflammasome through autophagy impairment and ROS accumulation in BV2 ce...

Additional file 2: Figure S2. of MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

Yan Zhou (6523)
Ming Lu (122276)
Ren-Hong Du (3472883)
Chen Qiao (710357)
Chun-Yi Jiang (3472892)
Ke-Zhong Zhang (3472886)
Jian-Hua Ding (3472889)
Gang Hu (132827)

April 2016

Aggregated α-syn activates NLRP3 inflammasome in BV2 cells. (a) Aggregated form of WT- and A53T α-Sy...

Additional file 6: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi (5799689)
Marcus Rust (5799692)
Sarah Kaiser (5799695)
Alexander Slowik (5799698)
Cordian Beyer (2733838)
Andreas Koczulla (3555509)
Jörg Schulz (4018502)
Pardes Habib (5799701)
Jan Bach (5799704)

September 2018

Figure S6. (A) 10 μM Aβ1–42 significantly increased caspase 1 mRNA. Co-treatment with A1AT blocked t...

Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system

Ayaka Nakanishi
Naoe Kaneko
Hiroyuki Takeda
Tatsuya Sawasaki
Shinnosuke Morikawa
Wei Zhou
Mie Kurata
Toshihiro Yamamoto
Sheikh Mohammad Fazle Akbar
Tamotsu Zako
Junya Masumoto

November 2018

Abstract Background Alzheimer’s disease is a neurodegenerative disease characterized by the intersti...

MOESM1 of RIP3 dependent NLRP3 inflammasome activation is implicated in acute lung injury in mice

Jingxian Chen (3125097)
Shuang Wang (46453)
Rong Fu (180787)
Mianjing Zhou (5647943)
Tengyue Zhang (5632472)
Wenxu Pan (5647946)
Niansheng Yang (5647949)
Yuefang Huang (5647952)

August 2018

Additional file 1: Figure S1. GSK872 had no effect on NF-κB or ERK signaling in LPS/ATP stimulated T...

Additional file 3: Figure S3. of The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-β peptide

Miriam Ries (3453977)
Rodrigo Loiola (3453980)
Urvi Shah (83424)
Steve Gentleman (3453983)
Egle Solito (390951)
Magdalena Sastre (3453974)

September 2016

ImageStream quantification of 5-FAM-labelled Aβ1–42 phagocytosis by BV2 cells. Histogram showing gat...

Additional file 1: of NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis

Carlo Marchetti (5594576)
Benjamin Swartzwelter (5594579)
Marije Koenders (3436682)
Tania Azam (64531)
Isak Tengesdal (5594582)
Nick Powers (5594585)
Dennis de Graaf (5594588)
Charles Dinarello (5594591)
Leo Joosten (26109)

August 2018

Figure S1. Effect of oral treatment with OLT1177 in zymosan-induced arthritis. a Mean ± SEM of joint...

Additional file 1: Figure S1. of The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway

Peter Sullivan (3547517)
Xiaolai Zhou (3547520)
Adam Robins (3547526)
Daniel Paushter (3547523)
Dongsung Kim (664168)
Marcus Smolka (413545)
Fenghua Hu (217655)

May 2016

Levels of endogenous versus overexpressed C9orf72 in N2a and HEK293T cells. N2a (a) and HEK293T (b) ...

Additional file 1: of The adhesion and migration of microglia to β-amyloid (Aβ) is decreased with aging and inhibited by Nogo/NgR pathway

Yinquan Fang (3409655)
Jianing Wang (465119)
Lemeng Yao (3409652)
Chenhui Li (697156)
Jing Wang (1228470)
Yuan Liu (88411)
Xia Tao (833990)
Hao Sun (14095)
Hong Liao (124443)

July 2018

Figure S1. Congo Red dye binding assay of fAβ1–42. The aggregation of fAβ1–42 was validated by the C...

Additional file 1: of Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system

Abstract

Extracted data

Additional file 1: of Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system

Abstract

Extracted data

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