PPh<sub>3</sub>AuTFA Catalyzed in the Dearomatization of 2‑Naphthols with Allenamides
- Juzeng An (3045333)
- Lorenzo Lombardi (5953355)
- Stefano Grilli (2254588)
- Marco Bandini (1668835)
Publication date
November 2018
DOI Publisher
American Chemical Society (ACS)Abstract
A new catalytic methodology for the direct dearomatization of substituted 2-naphthols via intermolecular condensation with allenamides is presented. PPh3AuTFA (5 mol %) promotes the formal allylating dearomative protocol under mild conditions, large scope (24 examples), and high regioselectivity and stereoselectivity. The synergistic catalytic role played by the [PPh3Au]+ (π-acid) and TFA– (Lewis base) is highlighted
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