(A and B) The time dependence of recovery from inactivation was measured with a triple-step voltage protocol (A). The inter-pulse interval varied from 1 to 1000 ms. The graph (B) plots the ratio of the INa amplitude evoked at the second depolarizing step to the INa amplitude evoked at the first depolarizing step (INa,2/INa,1) against the inter-pulse interval. p>0.05 between WT and RQ cells (rmANOVA). n, 5 WT and 5 RQ cells for each condition.</p
<p>(A) Steady-state inactivation of I<sub>Na</sub> was determined by holding cells at –70 mV and app...
(A and B) Representative traces (A) and mean I-V plots (B) of INa of WT and RQ cells continuously pe...
<p>(A−B) Representative current recordings in control conditions (upper) and after application of 18...
(A) The time dependence of inactivation was measured with a double-step voltage protocol (schematic ...
(A) Mean time course of the temperature at the center of the recording chamber after starting the ad...
(A) Mean relative peak g-V plots converted from the peak I-V plot in Fig 1B. The Boltzmann sigmoidal...
<p>(A) Voltage dependence of steady-state activation and inactivation curve of WT (open circle) and ...
<p>(A) Inactivation of Kv11.3 channels was investigated by a triple pulse protocol. Starting from a ...
<p>Representative current traces generated during the two-pulse protocol used to measure recovery fr...
<p>(A) Time course of development of fast inactivation with a pre-pulse of -45 mV. (B) τ values of d...
<p><b>a and b</b>, Top: voltage clamp (a) and VC/CC (b) protocols with an interpulse interval of 1–1...
<p><b>(A)</b> HEK293 cells expressing Ca<sub>V</sub>2.2, β<sub>1b</sub> and α<sub>2</sub>δ were stim...
<p>A: Envelope test during deactivation at −40 mV. After current activation at −130 mV, pulses to −4...
<p>A, Representative traces of recovery from fast inactivation measured by first inducing fast inact...
<p>(A) Family of I<sub>A</sub> currents at 7, 11, 15, 19, and 23°C elicited in response to depolariz...
<p>(A) Steady-state inactivation of I<sub>Na</sub> was determined by holding cells at –70 mV and app...
(A and B) Representative traces (A) and mean I-V plots (B) of INa of WT and RQ cells continuously pe...
<p>(A−B) Representative current recordings in control conditions (upper) and after application of 18...
(A) The time dependence of inactivation was measured with a double-step voltage protocol (schematic ...
(A) Mean time course of the temperature at the center of the recording chamber after starting the ad...
(A) Mean relative peak g-V plots converted from the peak I-V plot in Fig 1B. The Boltzmann sigmoidal...
<p>(A) Voltage dependence of steady-state activation and inactivation curve of WT (open circle) and ...
<p>(A) Inactivation of Kv11.3 channels was investigated by a triple pulse protocol. Starting from a ...
<p>Representative current traces generated during the two-pulse protocol used to measure recovery fr...
<p>(A) Time course of development of fast inactivation with a pre-pulse of -45 mV. (B) τ values of d...
<p><b>a and b</b>, Top: voltage clamp (a) and VC/CC (b) protocols with an interpulse interval of 1–1...
<p><b>(A)</b> HEK293 cells expressing Ca<sub>V</sub>2.2, β<sub>1b</sub> and α<sub>2</sub>δ were stim...
<p>A: Envelope test during deactivation at −40 mV. After current activation at −130 mV, pulses to −4...
<p>A, Representative traces of recovery from fast inactivation measured by first inducing fast inact...
<p>(A) Family of I<sub>A</sub> currents at 7, 11, 15, 19, and 23°C elicited in response to depolariz...
<p>(A) Steady-state inactivation of I<sub>Na</sub> was determined by holding cells at –70 mV and app...
(A and B) Representative traces (A) and mean I-V plots (B) of INa of WT and RQ cells continuously pe...
<p>(A−B) Representative current recordings in control conditions (upper) and after application of 18...