This study was designed to investigate possible interference of Xenobiotics with SUMOylation in eukaryotic cells. To begin with, we docked 71 chemical structures from PubChem with human SUMO1 and UBC9 protein structures using Auto Dock 4.2 and Hex 6.3 and selected five compounds for binding studies in Surface Plasmon Resonance (SPR) with human SUMO1. In SPR studies, only endosulfan showed binding to SUMO1 (Kd1.313 × 10-4 M). Further, we treated HePG2 and differentiated 3T3-L1 cells with endosulfan/bisphenol A/perfluorooctanoic acid (PFOA) to test induction of oxidative stress and SUMO isoform/UBC9 expression. Treatment with these compounds resulted in higher levels of nitric oxide (NO), NOS2A mRNA, and reactive oxygen species (ROS) associat...
Small Ubiquitin-like Modifier (SUMO) modification is a post-translational modification affecting man...
Bitkiler, biyotik ve abiyotik çevresel streslere yanıt oluşturabilirler. Bitkiler değişen çevre koş...
Post-translational modification by small ubiquitin-related modifier (SUMO) is a key regulator of cel...
Abstract Background In astrocytes, the inflammatory induction of Nitric Oxide Synthase type 2 (NOS2)...
SUMO-modification of nuclear proteins has profound effects on gene expression. However, non-toxic ch...
SummaryThe dynamic, posttranslational modification of proteins with a small ubiquitin-like modifier ...
Endosulfan is an organochlorine insecticide comprised of two isomers: endosulfan-α and endosulfan-β....
Our previous study showed that endosulfan increases the risk of cardiovascular disease. To identify ...
La SUMOylation est une modification post-traductionnelle réversible permettant de diversifier les fo...
During the activation and transferring process, E1 and E2 form a thioester-linkage with SUMOs. By us...
Liver X Receptors (LXRs) are ligand-activated transcription factors that regulate genes involved in ...
Bisphenol A (BPA) is an environmental endocrine disruptor which has been detected in human bodies. M...
<div><p>Bisphenol A (BPA) is an environmental endocrine disruptor which has been detected in human b...
Present study reports the identi fication of genomic and proteomic signatures of endosulfan exposure...
Oxidative stress in cells caused by excessive production of reactive oxygen species (ROS) and decrea...
Small Ubiquitin-like Modifier (SUMO) modification is a post-translational modification affecting man...
Bitkiler, biyotik ve abiyotik çevresel streslere yanıt oluşturabilirler. Bitkiler değişen çevre koş...
Post-translational modification by small ubiquitin-related modifier (SUMO) is a key regulator of cel...
Abstract Background In astrocytes, the inflammatory induction of Nitric Oxide Synthase type 2 (NOS2)...
SUMO-modification of nuclear proteins has profound effects on gene expression. However, non-toxic ch...
SummaryThe dynamic, posttranslational modification of proteins with a small ubiquitin-like modifier ...
Endosulfan is an organochlorine insecticide comprised of two isomers: endosulfan-α and endosulfan-β....
Our previous study showed that endosulfan increases the risk of cardiovascular disease. To identify ...
La SUMOylation est une modification post-traductionnelle réversible permettant de diversifier les fo...
During the activation and transferring process, E1 and E2 form a thioester-linkage with SUMOs. By us...
Liver X Receptors (LXRs) are ligand-activated transcription factors that regulate genes involved in ...
Bisphenol A (BPA) is an environmental endocrine disruptor which has been detected in human bodies. M...
<div><p>Bisphenol A (BPA) is an environmental endocrine disruptor which has been detected in human b...
Present study reports the identi fication of genomic and proteomic signatures of endosulfan exposure...
Oxidative stress in cells caused by excessive production of reactive oxygen species (ROS) and decrea...
Small Ubiquitin-like Modifier (SUMO) modification is a post-translational modification affecting man...
Bitkiler, biyotik ve abiyotik çevresel streslere yanıt oluşturabilirler. Bitkiler değişen çevre koş...
Post-translational modification by small ubiquitin-related modifier (SUMO) is a key regulator of cel...