Blocks to HIV transcription differ in the gut and blood.

Early Impairment of Gut Function and Gut Flora Supporting a Role for Alteration of Gastrointestinal Mucosa in Human

Immunodeficiency Virus Pathogenesis

January 2007

Our results show that impairment of the gastrointestinal tracts in human immunodeficiency virus (HIV...

Human Immunode®ciency Virus Type 1 (HIV-1) Infection and Expression in Intestinal Epithelial Cells: Role of Protein Kinase A and C Pathways

Martin F. Kagnoff

October 2016

Human immunode®ciency virus (HIV) can infect human colon epithelial cell lines by both CD4-dependent...

Primary and chronic HIV infection differently modulates mucosal Vδ1 and Vδ2 T-cells differentiation profile and effector functions

Cimini E.
Agrati C.
D'Offizi G.
Vlassi C.
Casetti R.
Sacchi A.
Lionetti R.
Bordoni V.
Tumino N.
Scognamiglio P.
Martini F.

January 2015

Gut-associated immune system has been identified as a major battlefield during the early phases of H...

Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency.

Sushama Telwatte
Sulggi Lee
Ma Somsouk
Hiroyu Hatano
Christopher Baker
Philipp Kaiser
Peggy Kim
Tsui-Hua Chen
Jeffrey Milush
Peter W Hunt
Steven G Deeks
Joseph K Wong
Steven A Yukl

November 2018

Latently-infected CD4+ T cells are widely considered to be the major barrier to a cure for HIV. Much...

Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency

Sushama Telwatte (5979593)
Sulggi Lee (5979596)
Ma Somsouk (283498)
Hiroyu Hatano (131626)
Christopher Baker (2499499)
Philipp Kaiser (712764)
Peggy Kim (5979599)
Tsui-Hua Chen (5979602)
Jeffrey Milush (5780147)
Peter W. Hunt (231174)
Steven G. Deeks (131630)
Joseph K. Wong (253893)
Steven A. Yukl (283479)

November 2018

Latently-infected CD4+ T cells are widely considered to be the major barrier to a cure for HIV. Much...

Levels of HIV DNA, 2-LTR circles, and blocks to transcription differ between CD4+ T cells from the gut and blood.

Sushama Telwatte (5979593)
Sulggi Lee (5979596)
Ma Somsouk (283498)
Hiroyu Hatano (131626)
Christopher Baker (2499499)
Philipp Kaiser (712764)
Peggy Kim (5979599)
Tsui-Hua Chen (5979602)
Jeffrey Milush (5780147)
Peter W. Hunt (231174)
Steven G. Deeks (131630)
Joseph K. Wong (253893)
Steven A. Yukl (283479)

November 2018

(A) Levels of HIV DNA (Long LTR region) and 2-LTR circles were quantified in CD4+ T cells from the b...

Mechanistic differences underlying HIV latency in the gut and blood contribute to differential responses to latency-reversing agents.

Telwatte, Sushama
Kim, Peggy
Chen, Tsui-Hua
Milush, Jeffrey M
Somsouk, Ma
Deeks, Steven G
Hunt, Peter W
Wong, Joseph K
Yukl, Steven A

November 2020

ObjectiveWhile latently HIV-infected cells have been described in the blood, it is unclear whether a...

Differences in HIV Burden and Immune Activation within the Gut of HIV-Positive Patients Receiving

Steven A. Yukl
Sara Gianella
A Elizabeth Sinclair
Lorrie Epling
Qingsheng Li
A Lijie Duan
Alex L. M. Choi
Valerie Girling
Terence Ho
Peilin Li
Katsuya Fujimoto
Harry Lampiris
C. Bradley Hare
Mark P
Ashley T. Haase
Huldrych F. Günthard
Marek Fischer
Eep K. Shergill
Kenneth Mcquaid
Diane V. Havlir
Joseph K. Wong

September 2016

Background. The gut is a major reservoir for human immunodeficiency virus (HIV) in patients receivin...

Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells.

Yukl, Steven A
Khan, Shahzada
Chen, Tsui-Hua
Trapecar, Martin
Wu, Frank
Xie, Guorui
Telwatte, Sushama
Fulop, Daniel
Pico, Alexander R
Laird, Gregory M
Ritter, Kristen D
Jones, Norman G
Lu, Chuanyi M
Siliciano, Robert F
Roan, Nadia R
Milush, Jeffrey M
Somsouk, Ma
Deeks, Steven G
Hunt, Peter W
Sanjabi, Shomyseh

December 2020

Latent HIV infection is the main barrier to cure, and most HIV-infected cells reside in the gut, whe...

Higher Frequency of NK and CD4+ T-Cells in Mucosa and Potent Cytotoxic Response in HIV Controllers.

Natalia Andrea Taborda
Sandra Milena González
Cristiam Mauricio Alvarez
Luis Alfonso Correa
Carlos Julio Montoya
María Teresa Rugeles

HIV infection induces immune alterations, mainly in gut mucosa, where the main target cells reside. ...

Microbial correlates with donor/recipient T cell activation and gut homing, and in vitro HIV infection.

Sam X. Li (176106)
Sharon Sen (3202434)
Jennifer M. Schneider (6555461)
Ka-Na Xiong (326480)
Nichole M. Nusbacher (6555464)
Nancy Moreno-Huizar (6555467)
Michael Shaffer (5933336)
Abigail J. S. Armstrong (6555470)
Erin Severs (6555473)
Kristine Kuhn (5542016)
Charles P. Neff (6555476)
Martin McCarter (3577136)
Thomas Campbell (5301196)
Catherine A. Lozupone (6555479)
Brent E. Palmer (349768)

April 2019

Microbial correlates with donor/recipient T cell activation and gut homing, and in vitro HIV infecti...

Mucosal cell populations may contribute to peripheral immune abnormalities in HIV-infected subjects introducing cART with moderate immune-suppression.

Matteo Basilissi
Camilla Tincati
Esther Merlini
Giuseppe Ancona
Elisa Borghi
Francesca Borgo
Alessandra Barassi
Antonella d'Arminio Monforte
Giulia Marchetti

January 2019

HIV infection causes the progressive depletion of CD4+ T-lymphocytes and profound modifications of T...

HIV RNA levels and HIV RNA/DNA ratios reveal blocks to elongation, distal transcription, and multiple-splicing in PBMCs and intact gut biopsies.

Sushama Telwatte (5979593)
Sulggi Lee (5979596)
Ma Somsouk (283498)
Hiroyu Hatano (131626)
Christopher Baker (2499499)
Philipp Kaiser (712764)
Peggy Kim (5979599)
Tsui-Hua Chen (5979602)
Jeffrey Milush (5780147)
Peter W. Hunt (231174)
Steven G. Deeks (131630)
Joseph K. Wong (253893)
Steven A. Yukl (283479)

November 2018

Read-through, total (TAR), 5’ elongated (R-U5/pre-Gag; “Long LTR”), Nef, polyadenylated (PolyA), and...

Higher Frequency of NK and CD4+ T-Cells in Mucosa and Potent Cytotoxic Response in HIV Controllers

Natalia Andrea Taborda (757703)
Sandra Milena González (5664904)
Cristiam Mauricio Alvarez (785271)
Luis Alfonso Correa (785272)
Carlos Julio Montoya (334838)
María Teresa Rugeles (5663890)

August 2015

<div>HIV infection induces immune alterations, mainly in gut mucosa, where the main target cells ...

Site-Specific Differences in T Cell Frequencies and Phenotypes in the Blood and Gut of HIVUninfected and ART-Treated HIV+ Adults

Yukl, Steven A.
Shergill, Amandeep K.
Girling, Valerie
Li, Qingsheng
Killian, Maudi
Epling, Lorrie
Li, Peilin
Kaiser, Philipp
Haase, Ashley
Havlir, Diane V.
McQuaid, Kenneth
Sinclair, Elizabeth
Wong, Joseph K.

January 2015

Gastrointestinal T lymphocytes are critical for mucosal immunity and HIV pathogenesis, yet little is...

Early Impairment of Gut Function and Gut Flora Supporting a Role for Alteration of Gastrointestinal Mucosa in Human

Immunodeficiency Virus Pathogenesis

January 2007

Our results show that impairment of the gastrointestinal tracts in human immunodeficiency virus (HIV...

Human Immunode®ciency Virus Type 1 (HIV-1) Infection and Expression in Intestinal Epithelial Cells: Role of Protein Kinase A and C Pathways

Martin F. Kagnoff

October 2016

Human immunode®ciency virus (HIV) can infect human colon epithelial cell lines by both CD4-dependent...

Primary and chronic HIV infection differently modulates mucosal Vδ1 and Vδ2 T-cells differentiation profile and effector functions

Cimini E.
Agrati C.
D'Offizi G.
Vlassi C.
Casetti R.
Sacchi A.
Lionetti R.
Bordoni V.
Tumino N.
Scognamiglio P.
Martini F.

January 2015

Gut-associated immune system has been identified as a major battlefield during the early phases of H...

Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency.

Sushama Telwatte
Sulggi Lee
Ma Somsouk
Hiroyu Hatano
Christopher Baker
Philipp Kaiser
Peggy Kim
Tsui-Hua Chen
Jeffrey Milush
Peter W Hunt
Steven G Deeks
Joseph K Wong
Steven A Yukl

November 2018

Latently-infected CD4+ T cells are widely considered to be the major barrier to a cure for HIV. Much...

Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency

Sushama Telwatte (5979593)
Sulggi Lee (5979596)
Ma Somsouk (283498)
Hiroyu Hatano (131626)
Christopher Baker (2499499)
Philipp Kaiser (712764)
Peggy Kim (5979599)
Tsui-Hua Chen (5979602)
Jeffrey Milush (5780147)
Peter W. Hunt (231174)
Steven G. Deeks (131630)
Joseph K. Wong (253893)
Steven A. Yukl (283479)

November 2018

Latently-infected CD4+ T cells are widely considered to be the major barrier to a cure for HIV. Much...

Levels of HIV DNA, 2-LTR circles, and blocks to transcription differ between CD4+ T cells from the gut and blood.

Sushama Telwatte (5979593)
Sulggi Lee (5979596)
Ma Somsouk (283498)
Hiroyu Hatano (131626)
Christopher Baker (2499499)
Philipp Kaiser (712764)
Peggy Kim (5979599)
Tsui-Hua Chen (5979602)
Jeffrey Milush (5780147)
Peter W. Hunt (231174)
Steven G. Deeks (131630)
Joseph K. Wong (253893)
Steven A. Yukl (283479)

November 2018

(A) Levels of HIV DNA (Long LTR region) and 2-LTR circles were quantified in CD4+ T cells from the b...

Mechanistic differences underlying HIV latency in the gut and blood contribute to differential responses to latency-reversing agents.

Telwatte, Sushama
Kim, Peggy
Chen, Tsui-Hua
Milush, Jeffrey M
Somsouk, Ma
Deeks, Steven G
Hunt, Peter W
Wong, Joseph K
Yukl, Steven A

November 2020

ObjectiveWhile latently HIV-infected cells have been described in the blood, it is unclear whether a...

Differences in HIV Burden and Immune Activation within the Gut of HIV-Positive Patients Receiving

Steven A. Yukl
Sara Gianella
A Elizabeth Sinclair
Lorrie Epling
Qingsheng Li
A Lijie Duan
Alex L. M. Choi
Valerie Girling
Terence Ho
Peilin Li
Katsuya Fujimoto
Harry Lampiris
C. Bradley Hare
Mark P
Ashley T. Haase
Huldrych F. Günthard
Marek Fischer
Eep K. Shergill
Kenneth Mcquaid
Diane V. Havlir
Joseph K. Wong

September 2016

Background. The gut is a major reservoir for human immunodeficiency virus (HIV) in patients receivin...

Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells.

Yukl, Steven A
Khan, Shahzada
Chen, Tsui-Hua
Trapecar, Martin
Wu, Frank
Xie, Guorui
Telwatte, Sushama
Fulop, Daniel
Pico, Alexander R
Laird, Gregory M
Ritter, Kristen D
Jones, Norman G
Lu, Chuanyi M
Siliciano, Robert F
Roan, Nadia R
Milush, Jeffrey M
Somsouk, Ma
Deeks, Steven G
Hunt, Peter W
Sanjabi, Shomyseh

December 2020

Latent HIV infection is the main barrier to cure, and most HIV-infected cells reside in the gut, whe...

Higher Frequency of NK and CD4+ T-Cells in Mucosa and Potent Cytotoxic Response in HIV Controllers.

Natalia Andrea Taborda
Sandra Milena González
Cristiam Mauricio Alvarez
Luis Alfonso Correa
Carlos Julio Montoya
María Teresa Rugeles

HIV infection induces immune alterations, mainly in gut mucosa, where the main target cells reside. ...

Microbial correlates with donor/recipient T cell activation and gut homing, and in vitro HIV infection.

Sam X. Li (176106)
Sharon Sen (3202434)
Jennifer M. Schneider (6555461)
Ka-Na Xiong (326480)
Nichole M. Nusbacher (6555464)
Nancy Moreno-Huizar (6555467)
Michael Shaffer (5933336)
Abigail J. S. Armstrong (6555470)
Erin Severs (6555473)
Kristine Kuhn (5542016)
Charles P. Neff (6555476)
Martin McCarter (3577136)
Thomas Campbell (5301196)
Catherine A. Lozupone (6555479)
Brent E. Palmer (349768)

April 2019

Microbial correlates with donor/recipient T cell activation and gut homing, and in vitro HIV infecti...

Mucosal cell populations may contribute to peripheral immune abnormalities in HIV-infected subjects introducing cART with moderate immune-suppression.

Matteo Basilissi
Camilla Tincati
Esther Merlini
Giuseppe Ancona
Elisa Borghi
Francesca Borgo
Alessandra Barassi
Antonella d'Arminio Monforte
Giulia Marchetti

January 2019

HIV infection causes the progressive depletion of CD4+ T-lymphocytes and profound modifications of T...

HIV RNA levels and HIV RNA/DNA ratios reveal blocks to elongation, distal transcription, and multiple-splicing in PBMCs and intact gut biopsies.

Sushama Telwatte (5979593)
Sulggi Lee (5979596)
Ma Somsouk (283498)
Hiroyu Hatano (131626)
Christopher Baker (2499499)
Philipp Kaiser (712764)
Peggy Kim (5979599)
Tsui-Hua Chen (5979602)
Jeffrey Milush (5780147)
Peter W. Hunt (231174)
Steven G. Deeks (131630)
Joseph K. Wong (253893)
Steven A. Yukl (283479)

November 2018

Read-through, total (TAR), 5’ elongated (R-U5/pre-Gag; “Long LTR”), Nef, polyadenylated (PolyA), and...

Higher Frequency of NK and CD4+ T-Cells in Mucosa and Potent Cytotoxic Response in HIV Controllers

Natalia Andrea Taborda (757703)
Sandra Milena González (5664904)
Cristiam Mauricio Alvarez (785271)
Luis Alfonso Correa (785272)
Carlos Julio Montoya (334838)
María Teresa Rugeles (5663890)

August 2015

<div>HIV infection induces immune alterations, mainly in gut mucosa, where the main target cells ...

Site-Specific Differences in T Cell Frequencies and Phenotypes in the Blood and Gut of HIVUninfected and ART-Treated HIV+ Adults

Yukl, Steven A.
Shergill, Amandeep K.
Girling, Valerie
Li, Qingsheng
Killian, Maudi
Epling, Lorrie
Li, Peilin
Kaiser, Philipp
Haase, Ashley
Havlir, Diane V.
McQuaid, Kenneth
Sinclair, Elizabeth
Wong, Joseph K.

January 2015

Gastrointestinal T lymphocytes are critical for mucosal immunity and HIV pathogenesis, yet little is...

Early Impairment of Gut Function and Gut Flora Supporting a Role for Alteration of Gastrointestinal Mucosa in Human

Immunodeficiency Virus Pathogenesis

January 2007

Our results show that impairment of the gastrointestinal tracts in human immunodeficiency virus (HIV...

Human Immunode®ciency Virus Type 1 (HIV-1) Infection and Expression in Intestinal Epithelial Cells: Role of Protein Kinase A and C Pathways

Martin F. Kagnoff

October 2016

Human immunode®ciency virus (HIV) can infect human colon epithelial cell lines by both CD4-dependent...

Primary and chronic HIV infection differently modulates mucosal Vδ1 and Vδ2 T-cells differentiation profile and effector functions

Cimini E.
Agrati C.
D'Offizi G.
Vlassi C.
Casetti R.
Sacchi A.
Lionetti R.
Bordoni V.
Tumino N.
Scognamiglio P.
Martini F.

January 2015

Gut-associated immune system has been identified as a major battlefield during the early phases of H...

Blocks to HIV transcription differ in the gut and blood.

Abstract

Extracted data

Blocks to HIV transcription differ in the gut and blood.

Abstract

Extracted data

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