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A critical requirement for developing a cyber capable workforce is to understand how to challenge, assess, and rapidly develop human cyber skill-sets in realistic cyber operational environments. Fortunately, cyber team competitions make use of simulated operational environments with scoring criteria of task performance that objectively define overall team effectiveness, thus providing the means and context for observation and analysis of cyber teaming. Such competitions allow researchers to address the key determinants that make a cyber defense team more or less effective in responding to and mitigating cyber attacks. For this purpose, we analyzed data collected at the 12th annual Mid-Atlantic Collegiate Cyber Defense Competition (MACCDC, http://www.maccdc.org), where eight teams were evaluated along four independent scoring dimensions: maintaining services, incident response, scenario injects, and thwarting adversarial activities. Data collected from the 13-point OAT (Observational Assessment of Teamwork) instrument by embedded observers and a cyber teamwork survey completed by all participants were used to assess teamwork and leadership behaviors and team composition and work processes, respectively. The scores from the competition were used as an outcome measure in our analysis to extract key features of team process, structure, leadership, and skill-sets in relation to effective cyber defense. We used Bayesian regression to relate scored performance during the competition to team skill composition, team experience level, and an observational construct of team collaboration. Our results indicate that effective collaboration, experience, and functional role-specialization within the teams are important factors that determine the success of these teams in the competition and are important observational predictors of the timely detection and effective mitigation of ongoing cyber attacks. These results support theories of team maturation and the development of functional team cognition applied to mastering cybersecurity.