Sirtuin 5 (SIRT5) is a member of the family of NAD+-dependent lysine/histone deacetylases. SIRT5 resides mainly in the mitochondria where it catalyzes deacetylation, demalonylation, desuccinylation, and deglutarylation of lysine to regulate metabolic and oxidative stress response pathways. Pharmacologic inhibitors of SIRT5 are under development for oncologic conditions, but nothing is known about the impact of SIRT5 on antimicrobial innate immune defenses. Using SIRT5 knockout mice, we show that SIRT5 deficiency does not affect immune cell development, cytokine production and proliferation by macrophages and splenocytes exposed to microbial and immunological stimuli. Moreover, preclinical models suggest that SIRT5 deficiency does not worsen...
Sirtuins are NAD–dependent deacetylases that regulate important biological processes. Four mammalia...
SIRT2 belongs to a highly conserved family of NAD+-dependent deacylases, consisting of seven members...
Over the past several years, SIRT5 has attracted considerable attention in metabolic regulation. How...
Sirtuin 5 (SIRT5) is a member of the family of NAD+-dependent lysine/histone deacetylases. SIRT5 res...
Sirtuin 5 (SIRT5) is a member of the family of NAD+-dependent lysine/histone deacetylases. SIRT5 res...
Sirtuin 5 (SIRT5) is a member of the family of NAD <sup>+</sup> -dependent lysine/histon...
The sirtuins SIRT3 and SIRT5 are the main mitochondrial lysine deacetylase and desuccinylase, respec...
Sirtuin 2 (SIRT2) is one of the seven members of the family of NAD(+)-dependent histone deacetylases...
Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase. SIRT3 regulates cell metabolism and redox h...
Sirtuin 2 (SIRT2) is one of the seven members of the family of NAD(+)-dependent histone deacetylases...
Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase. SIRT3 regulates cell metabolism and redox h...
Sirtuin 2 (SIRT2) and SIRT3 are cytoplasmic and mitochondrial NAD-dependent deacetylases. SIRT2 and ...
Purpose/Objective: Histone deacetylases (HDACs) deacetylate histones and transcriptional regulators ...
<p>Addition of a SIRT1 agonist (resveratrol) or antagonist (sirtinol) has no effect on the antimicro...
<div><p>The role of sirtuin-1 (SIRT1) in innate immunity, and in particular the influence of SIRT1 o...
Sirtuins are NAD–dependent deacetylases that regulate important biological processes. Four mammalia...
SIRT2 belongs to a highly conserved family of NAD+-dependent deacylases, consisting of seven members...
Over the past several years, SIRT5 has attracted considerable attention in metabolic regulation. How...
Sirtuin 5 (SIRT5) is a member of the family of NAD+-dependent lysine/histone deacetylases. SIRT5 res...
Sirtuin 5 (SIRT5) is a member of the family of NAD+-dependent lysine/histone deacetylases. SIRT5 res...
Sirtuin 5 (SIRT5) is a member of the family of NAD <sup>+</sup> -dependent lysine/histon...
The sirtuins SIRT3 and SIRT5 are the main mitochondrial lysine deacetylase and desuccinylase, respec...
Sirtuin 2 (SIRT2) is one of the seven members of the family of NAD(+)-dependent histone deacetylases...
Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase. SIRT3 regulates cell metabolism and redox h...
Sirtuin 2 (SIRT2) is one of the seven members of the family of NAD(+)-dependent histone deacetylases...
Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase. SIRT3 regulates cell metabolism and redox h...
Sirtuin 2 (SIRT2) and SIRT3 are cytoplasmic and mitochondrial NAD-dependent deacetylases. SIRT2 and ...
Purpose/Objective: Histone deacetylases (HDACs) deacetylate histones and transcriptional regulators ...
<p>Addition of a SIRT1 agonist (resveratrol) or antagonist (sirtinol) has no effect on the antimicro...
<div><p>The role of sirtuin-1 (SIRT1) in innate immunity, and in particular the influence of SIRT1 o...
Sirtuins are NAD–dependent deacetylases that regulate important biological processes. Four mammalia...
SIRT2 belongs to a highly conserved family of NAD+-dependent deacylases, consisting of seven members...
Over the past several years, SIRT5 has attracted considerable attention in metabolic regulation. How...