Figure S1. Immunoblotting data of main Fig. 1a-c were quantified using Image J software. Data were the mean ± S.E.M. from 3 independent experiments. *p < 0.05, indicating the enhanced effects of ATP, BzATP and nigericin; #p < 0.05, indicating the antagonist effects of A438079 and/or P2X7−/− on the individual action of ATP and BzATP. (TIF 3316 kb
α-Synuclein activates NLRP3 inflammasome through autophagy impairment and ROS accumulation in BV2 ce...
APN deficiency reduced the level of phosphorylated AMPK in 5xFAD mice. (a) Representative image of i...
Figure S2. Primary microglia viability was detected by MTS assay. Primary microglia was treated with...
Figure S3. Immunoblotting analysis of main Fig. 3 were quantified using Image J software. Data were ...
Figure S2. Immunoblotting data of main Fig. 2c, d and f were quantified using Image J software and s...
Cultured human microglia do not bleb in response to ATP. Microglia cultured on chamber slides were e...
Concentration and time-dependent responses of microglia in IL1β release upon LPS plus BzATP stimulat...
Figure S3. P2X7Rs do not regulate microglial intracellular pH, IL-1β/IL-18 release, blebbing, or pho...
Figure S4. P2X7R dye uptake is independent of cell lysis and selective for cations below a certain t...
Figure S2. Microglia P2X7Rs are dynamically regulated by bacterial phagocytosis. (a) The current-vol...
Figure S1. Ivermectin potentiates P2X7R current. ATP was applied every 15 s in the absence and prese...
A-769662 activated AMPK downstream targets involved in regulation of mitochondrial function. BMDMs w...
PKD family inhibition abrogates LPA-mediated downstream signaling. (A) BV-2 microglia cells were cul...
LPAR5 controls LPA-mediated downstream signaling. (A) BV-2 microglia cells were cultured in 6-well p...
Figure S1. A) Von Frey filament, and grip strength analysis for BupOH and TTX at days 1 and 5. B) Vo...
α-Synuclein activates NLRP3 inflammasome through autophagy impairment and ROS accumulation in BV2 ce...
APN deficiency reduced the level of phosphorylated AMPK in 5xFAD mice. (a) Representative image of i...
Figure S2. Primary microglia viability was detected by MTS assay. Primary microglia was treated with...
Figure S3. Immunoblotting analysis of main Fig. 3 were quantified using Image J software. Data were ...
Figure S2. Immunoblotting data of main Fig. 2c, d and f were quantified using Image J software and s...
Cultured human microglia do not bleb in response to ATP. Microglia cultured on chamber slides were e...
Concentration and time-dependent responses of microglia in IL1β release upon LPS plus BzATP stimulat...
Figure S3. P2X7Rs do not regulate microglial intracellular pH, IL-1β/IL-18 release, blebbing, or pho...
Figure S4. P2X7R dye uptake is independent of cell lysis and selective for cations below a certain t...
Figure S2. Microglia P2X7Rs are dynamically regulated by bacterial phagocytosis. (a) The current-vol...
Figure S1. Ivermectin potentiates P2X7R current. ATP was applied every 15 s in the absence and prese...
A-769662 activated AMPK downstream targets involved in regulation of mitochondrial function. BMDMs w...
PKD family inhibition abrogates LPA-mediated downstream signaling. (A) BV-2 microglia cells were cul...
LPAR5 controls LPA-mediated downstream signaling. (A) BV-2 microglia cells were cultured in 6-well p...
Figure S1. A) Von Frey filament, and grip strength analysis for BupOH and TTX at days 1 and 5. B) Vo...
α-Synuclein activates NLRP3 inflammasome through autophagy impairment and ROS accumulation in BV2 ce...
APN deficiency reduced the level of phosphorylated AMPK in 5xFAD mice. (a) Representative image of i...
Figure S2. Primary microglia viability was detected by MTS assay. Primary microglia was treated with...