A spreadsheet containing all the raw gRNA read counts for each of the screens performed in this study. The gRNAs and the gene promoter targeted are listed in the rows, and the experiments in the columns: “plasmid” refers to the lentiviral gRNA library counts prior to transformation; “d7” and “d12-transduced” refer to gRNA counts from cells 7 and 12 days after transduction; “8aB_rep” to the three replicates for the pooled monoclonal antibody screen; and the remaining columns list the protein probes used for selection in the screens. (XLSX 5146 kb
Figure S2. PCR amplification of sgRNA region for deep-sequencing analysis. (A) Successful transfecti...
Quantification of NGS read number and GC content for the four analysed NGS sequencing samples. (PDF ...
Table S1. (A) Correlation between predicted activity and target site conservation. (B) Correlation b...
Table S1. A table listing the gRNAs sequences targeting the promoter regions for the named genes. Th...
A table detailing all the gRNA sequences present in the CRISPRa library. For each named gene, the gR...
Figure S1. CRISPR activation enables rapid and stable upregulation of cell surface proteins. Figure ...
Functional analysis of CORALINA gRNAs. (A) List of most frequently sequenced alteration generated wi...
List of gRNAs, their target location, and target strand (template or non-template). (XLSX 81 kb
Files S1 - S6 contain underlying data for figures published in the paper. S1: sgRNA counts of unsor...
Figure S1. CRISPR screening of a collection of sgRNAsiBAR-ANTXR1 containing all 4096 types of iBAR6 ...
Table S4. Results of the human genome-scale sgRNAiBAR library screening at different MOI for the cyt...
Table S2. Raw NGS count table for FACS-based CRISPR screening using constitutive sgRNA expression ve...
Figure S1. Schematic of drug-inducible sgRNA expression lentiviral vectors. Figure S2. Nucleotide se...
Figure S1. (A) gRNAs were selected for functional testing based on the number of sequences targeted ...
Table S1. Target sequences within the CCR5 gene of engineered nucleases. Table S2. Primers used for ...
Figure S2. PCR amplification of sgRNA region for deep-sequencing analysis. (A) Successful transfecti...
Quantification of NGS read number and GC content for the four analysed NGS sequencing samples. (PDF ...
Table S1. (A) Correlation between predicted activity and target site conservation. (B) Correlation b...
Table S1. A table listing the gRNAs sequences targeting the promoter regions for the named genes. Th...
A table detailing all the gRNA sequences present in the CRISPRa library. For each named gene, the gR...
Figure S1. CRISPR activation enables rapid and stable upregulation of cell surface proteins. Figure ...
Functional analysis of CORALINA gRNAs. (A) List of most frequently sequenced alteration generated wi...
List of gRNAs, their target location, and target strand (template or non-template). (XLSX 81 kb
Files S1 - S6 contain underlying data for figures published in the paper. S1: sgRNA counts of unsor...
Figure S1. CRISPR screening of a collection of sgRNAsiBAR-ANTXR1 containing all 4096 types of iBAR6 ...
Table S4. Results of the human genome-scale sgRNAiBAR library screening at different MOI for the cyt...
Table S2. Raw NGS count table for FACS-based CRISPR screening using constitutive sgRNA expression ve...
Figure S1. Schematic of drug-inducible sgRNA expression lentiviral vectors. Figure S2. Nucleotide se...
Figure S1. (A) gRNAs were selected for functional testing based on the number of sequences targeted ...
Table S1. Target sequences within the CCR5 gene of engineered nucleases. Table S2. Primers used for ...
Figure S2. PCR amplification of sgRNA region for deep-sequencing analysis. (A) Successful transfecti...
Quantification of NGS read number and GC content for the four analysed NGS sequencing samples. (PDF ...
Table S1. (A) Correlation between predicted activity and target site conservation. (B) Correlation b...