Chelation of endogenous Zn<sup>2+</sup> inhibits CA1-LTP.
- John A. Sullivan (6018725)
- Xiao-lei Zhang (350996)
- Arthur P. Sullivan (6018728)
- Linnea R. Vose (6018731)
- Alexander A. Moghadam (6018734)
- Victor A. Fried (6018737)
- Patric K. Stanton (351000)
Publication date
November 2018
DOI Publisher
Public Library of Science (PLoS)Abstract
(A) Bath application (solid bar) of the Zn2+ chelater 1mM CaEDTA (open triangles, n = 7) significantly reduced the magnitude of SCH-CA1 LTP compared to untreated control slices (dark circles, n = 7). Bath application of the Zn2+ chelator 50μM TPEN (solid bar) converted control LTP to LTD (light circles, n = 6; Comparison of three groups P(B) Summary of mean ± SEM fEPSP slopes 50 minutes post-TBS for untreated control slices versus slices pre-treated with 1mM CaEDTA (*, PP<0.05; Dunnett’s post hoc test).</p
Add to ORKG