Cerebral palsy (CP) encompasses a group of non-progressive brain disorders that are often acquired through perinatal hypoxic-ischemic (HI) brain injury. Injury leads to a cascade of cell death events, resulting in lifetime motor and cognitive deficits. There are currently no treatments that can repair the resulting brain damage and improve functional outcomes. To date, preclinical research using neural precursor cell (NPC) transplantation as a therapy for HI brain injury has shown promise. To translate this treatment to the clinic, it is essential that human-derived NPCs also be tested in animal models, however, a major limitation is the high risk of xenograft rejection. A solution is to transplant the cells into immune-deficient rodents, b...
A critical issue in animal models of perinatal brain injury is to adapt the pertinent pathophysiolog...
Introduction: Nowadays, the important role of stem cells in treatment of many diseases such as stoke...
International audienceCerebral palsy is a major health problem caused by brain damage during pregnan...
Cerebral palsy (CP) encompasses a group of non-progressive brain disorders that are often acquired t...
Perinatal hypoxia ischemia (HI) is a significant cause of brain damage leading to motor and cognitiv...
Neonatal hypoxic-ischemic brain injury (HIE) remains a major cause of neurologic disabilities. Howev...
Cerebral palsy (CP) is a complex multifactorial disorder, affecting approximately 2.5-3/1000 live te...
ABSTRACT: Brain damage around birth may cause lifelong neu-rodevelopmental deficits. We examined the...
Human umbilical cord blood mononuclear cells (HUCB) have been shown to have a therapeutic role in di...
Background and Purpose—Hypoxic–ischemic (HI) brain injury in newborn infants represents a major caus...
Human umbilical cord blood mononuclear cells (HUCB) have been shown to have a therapeutic role in di...
We intended to determine whether transplanted neural precursors, derived from mouse embryonic stem (...
Background: Brain hypoxia-ischemia is a human neonatal injury that is considered a candidate for ste...
Hypoxia/ischemia encephalopathy is a major contributor to the development of acute neonatal neurodev...
Neonatal hypoxia-ischemia (HI) and ischemia are a common cause of neonatal brain injury resulting in...
A critical issue in animal models of perinatal brain injury is to adapt the pertinent pathophysiolog...
Introduction: Nowadays, the important role of stem cells in treatment of many diseases such as stoke...
International audienceCerebral palsy is a major health problem caused by brain damage during pregnan...
Cerebral palsy (CP) encompasses a group of non-progressive brain disorders that are often acquired t...
Perinatal hypoxia ischemia (HI) is a significant cause of brain damage leading to motor and cognitiv...
Neonatal hypoxic-ischemic brain injury (HIE) remains a major cause of neurologic disabilities. Howev...
Cerebral palsy (CP) is a complex multifactorial disorder, affecting approximately 2.5-3/1000 live te...
ABSTRACT: Brain damage around birth may cause lifelong neu-rodevelopmental deficits. We examined the...
Human umbilical cord blood mononuclear cells (HUCB) have been shown to have a therapeutic role in di...
Background and Purpose—Hypoxic–ischemic (HI) brain injury in newborn infants represents a major caus...
Human umbilical cord blood mononuclear cells (HUCB) have been shown to have a therapeutic role in di...
We intended to determine whether transplanted neural precursors, derived from mouse embryonic stem (...
Background: Brain hypoxia-ischemia is a human neonatal injury that is considered a candidate for ste...
Hypoxia/ischemia encephalopathy is a major contributor to the development of acute neonatal neurodev...
Neonatal hypoxia-ischemia (HI) and ischemia are a common cause of neonatal brain injury resulting in...
A critical issue in animal models of perinatal brain injury is to adapt the pertinent pathophysiolog...
Introduction: Nowadays, the important role of stem cells in treatment of many diseases such as stoke...
International audienceCerebral palsy is a major health problem caused by brain damage during pregnan...