Illustration of PSIR acquisition on two motor neuron disease patients.

A) Sagittal short tau inversion recovery (STIR) image used to prescribe the PSIR acquisitions at the four cervical disc levels (yellow lines). B-E) PSIR acquisitions (phase-sensitive reconstructed images are shown) of a patient with predominantly bulbar symptoms at C2-C3, C3-C4, C5-C6 and C7-T1 disc level, respectively; F-I) PSIR acquisitions of the patient with PLS at C2-C3, C3-C4, C5-C6 and C7-T1 disc level, respectively. Notice how gray and white matter are visibly reduced at all four levels in the PLS patient when compared with the patient with bulbar involvement.