TargetClone: A multi-sample approach for reconstructing subclonal evolution of tumors - Fig 4

(A) Mean of the error rates and 95% confidence intervals as a function of different tumor fractions at a sequencing noise level of 0.02. Every μ was tested once. (B) The blue line shows the average fraction of ambiguous alleles that are present in 101 simulated datasets, each with a different tumor fraction between 0 and 1. The orange line indicates the mean and 95% confidence intervals of resolved ambiguities, normalized by the size of . (C) Mean of the tree reconstruction error rates and 95% confidence intervals as a function of the number of subclones in the sample. A total of 100 simulations were performed for each number of subclones, for each of which a noise level of 0.02 and μ of 0.9 was selected. Each line shows the total percentage of the contaminating minor subclones in each sample. Every contamination percentage within the shown range was tested once.