Alzheimer’s disease (AD) is a chronic neurodegenerative disorder that is associated with the most common type of dementia and is characterized by the presence of deposits of the protein fragment amyloid beta (Aβ) in the brain. The natural product mixture of curcuminoids that improves certain defects in innate immune cells of AD patients may selectively enhance Aβ phagocytosis by alteration of gene transcription. In this work, we evaluated the protective effects of curcuminoids in cells from AD patients by investigating the effect on NF-κB and BACE1 signaling pathways. These results were compared to the gene expression profile of the clearance of Aβ. The minor curcumin constituent, bisdemethoxycurcumin (BDC) showed the most potent protective...
With the trend of an increasing aged population worldwide, Alzheimer's disease (AD), an age-related ...
Alzheimer’s disease is likely to be caused by copathogenic factors including aggregation of Aβ pepti...
Aggregation of amyloid beta protein (Aβ) and phosphorylated tau (p-Tau) plays critical roles in path...
Alzheimer’s disease (AD) is a chronic neurodegenerative disorder that is associated with the most co...
Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is associated with the most co...
Curcumin derived from turmeric is well documented for its anti-carcinogenic, antioxidant and anti-in...
Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive cognitive imp...
Pamela E Potter Department of Pharmacology, Arizona College of Osteopathic Medicine, Midwestern Univ...
The observation of down-regulation of BACE1 and NF-kB following administration of BDC to cells from...
Alzheimer\u27s disease (AD) is a neurodegenerative disorder, which depicts features of chronic infla...
The multifactorial character of Alzheimer’s disease (AD) represents a significant impediment to achi...
Curcumin is the primary curcuminoid found in the rhizome of the turmeric plant (Curcuma longa), resp...
: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is not restricted to the...
Neurodegenerative diseases (NDs) are one of major public health problems and their impact is continu...
AD is a chronic neurodegenerative disease. Many different signaling pathways, such as Wnt/β-catenin,...
With the trend of an increasing aged population worldwide, Alzheimer's disease (AD), an age-related ...
Alzheimer’s disease is likely to be caused by copathogenic factors including aggregation of Aβ pepti...
Aggregation of amyloid beta protein (Aβ) and phosphorylated tau (p-Tau) plays critical roles in path...
Alzheimer’s disease (AD) is a chronic neurodegenerative disorder that is associated with the most co...
Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is associated with the most co...
Curcumin derived from turmeric is well documented for its anti-carcinogenic, antioxidant and anti-in...
Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive cognitive imp...
Pamela E Potter Department of Pharmacology, Arizona College of Osteopathic Medicine, Midwestern Univ...
The observation of down-regulation of BACE1 and NF-kB following administration of BDC to cells from...
Alzheimer\u27s disease (AD) is a neurodegenerative disorder, which depicts features of chronic infla...
The multifactorial character of Alzheimer’s disease (AD) represents a significant impediment to achi...
Curcumin is the primary curcuminoid found in the rhizome of the turmeric plant (Curcuma longa), resp...
: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is not restricted to the...
Neurodegenerative diseases (NDs) are one of major public health problems and their impact is continu...
AD is a chronic neurodegenerative disease. Many different signaling pathways, such as Wnt/β-catenin,...
With the trend of an increasing aged population worldwide, Alzheimer's disease (AD), an age-related ...
Alzheimer’s disease is likely to be caused by copathogenic factors including aggregation of Aβ pepti...
Aggregation of amyloid beta protein (Aβ) and phosphorylated tau (p-Tau) plays critical roles in path...