DEN induced HCC is associated with expanding nodular pattern during hepatocarcinogenesis.
- Anindita Tripathy (6041567)
- Sudhir Thakurela (398994)
- Manoj Kumar Sahu (480417)
- Kanishka Uthanasingh (6041570)
- Manas Behera (6041573)
- Amrendra Kumar Ajay (134450)
- Ratna Kumari (402643)
Publication date
December 2018
DOI Publisher
Public Library of Science (PLoS)Abstract
The expanding nodular pattern of HCC in male wistar rats. (A) Formation of focal lesions in DEN+CCl4 treated rats. Animals sacrificed at different stages of hepatocarcinogenesis. (B) The different patterns of nodular lesions observed in DEN+CCl4 treated animals- control (a); diffused (b), multi-nodular (c), and massive (d). (C) Estimation of bilirubin showing constantly increasing level in DEN+CCl4 treated animals. (D) Measurement of liver weight showing increasing trend at different time points in the treated group, which belonged to different stages of hepatocarcinogenesis. Data presented are expressed as Mean±S.D. *ppp<0.0005.</p
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