Cellular glucose uptake was determined in NV and E4 cells treated with no insulin (Control), or treated with insulin plus IR inhibitor (S961), IGF-1R inhibitor (PPP), S961+PPP combined (S961+PPP), or PI3K inhibitor (WM). The treatments were compared using one-way ANOVA and post hoc Tukey’s HSD test, p≤0.05. Treatment sharing letters are not statistically significant.</p
The insulin-stimulated uptake of glucose by muscle and adipose is vital for the maintenance of gluco...
OBJECTIVE—The goal of this study was to evaluate the performance of surrogate measures of insulin se...
<p><b>a</b>, Chemical structure of P1736. <b>b</b>, Insulin stimulated glucose uptake in normal a...
pAKT abundance, normalized to AKT abundance was determined in NV cells treated with no insulin (Cont...
pAS160 abundance was determined in NV and E4 cells treated with no insulin or with insulin or insuli...
pAKT abundance was determined in NV and E4 cells treated with no insulin (Control, A), insulin (B) o...
Translocation of Glut4 to cell membrane was determined in NV and E4 cells treated with no insulin (C...
<p>Glucose uptake (A and B) and glycogen storage (C) of HepG2 cells incubated in DMEM with 5.5 mM gl...
<p>3T3-L1 adipocytes were serum-starved for 16 h. For the inhibitor treatment, the cells were pretre...
<p>L6 cells were maintained in normal-glucose (5 mM) or high-glucose (25 mM) medium. Cells were trea...
<p>(A), (B) The 2DG uptake level in SC cells or KD cells with or without insulin treatment was evalu...
<p>Data are presented as the mean ± SD of glucose uptake divided by the optical density determined i...
BackgroundType 2 diabetes is often linked with impaired proximal insulin signaling. Hence, a therape...
Background: Two direct measurements of peripheral insulin sensitivity are the M value derived from t...
<p>Supernatants collected from glucose-stimulated INS-1E cells (20 mM glucose, 90 min, 37°C) were me...
The insulin-stimulated uptake of glucose by muscle and adipose is vital for the maintenance of gluco...
OBJECTIVE—The goal of this study was to evaluate the performance of surrogate measures of insulin se...
<p><b>a</b>, Chemical structure of P1736. <b>b</b>, Insulin stimulated glucose uptake in normal a...
pAKT abundance, normalized to AKT abundance was determined in NV cells treated with no insulin (Cont...
pAS160 abundance was determined in NV and E4 cells treated with no insulin or with insulin or insuli...
pAKT abundance was determined in NV and E4 cells treated with no insulin (Control, A), insulin (B) o...
Translocation of Glut4 to cell membrane was determined in NV and E4 cells treated with no insulin (C...
<p>Glucose uptake (A and B) and glycogen storage (C) of HepG2 cells incubated in DMEM with 5.5 mM gl...
<p>3T3-L1 adipocytes were serum-starved for 16 h. For the inhibitor treatment, the cells were pretre...
<p>L6 cells were maintained in normal-glucose (5 mM) or high-glucose (25 mM) medium. Cells were trea...
<p>(A), (B) The 2DG uptake level in SC cells or KD cells with or without insulin treatment was evalu...
<p>Data are presented as the mean ± SD of glucose uptake divided by the optical density determined i...
BackgroundType 2 diabetes is often linked with impaired proximal insulin signaling. Hence, a therape...
Background: Two direct measurements of peripheral insulin sensitivity are the M value derived from t...
<p>Supernatants collected from glucose-stimulated INS-1E cells (20 mM glucose, 90 min, 37°C) were me...
The insulin-stimulated uptake of glucose by muscle and adipose is vital for the maintenance of gluco...
OBJECTIVE—The goal of this study was to evaluate the performance of surrogate measures of insulin se...
<p><b>a</b>, Chemical structure of P1736. <b>b</b>, Insulin stimulated glucose uptake in normal a...