(A) Proposed mechanism in which water molecules around mevalonate may deprotonate the C5-hydroxyl group of the substrate, assisted by conserved Asp138 acting as a base, to trigger phosphoryl transfer from ATP. (B) The alternative direct phosphorylation mechanism, in which the C5-hydroxyl group of mevalonate is deprotonated by the γ-phosphate group of ATP.</p
The catalytic mechanism that involves the cleavage of the phosphate diester model <b>BDNPP</b> (bis...
Fe3+, stabilised by the N7 group on adenine, interacts with the dianion of ADP, lowering the pKa of ...
Adenosine triphosphate (ATP) is the main biological phosphoryl donor required in many enzymes includ...
The mevalonate pathway is of important clinical, pharmaceutical, and biotechnological relevance. How...
Mevalonate pathway is of important clinical, pharmaceutical and biotechnological relevance.However, ...
Mevalonate Kinase (MVK) catalyses the ATP-Mg2+ mediated phosphate transfer of mevalonate to produce ...
Phosphate transfer reactions are catalyzed by a large number of enzymes comprising kinases, mutases ...
Protein kinases, representing one of the largest protein families involved in almost all aspects of ...
AbstractBackground: Phosphoryl transfer, typically involving high energy phosphate donors such as AT...
Isoprenoids make up a remarkably diverse class of more than 25000 biomolecules that include familiar...
An attempt is made to draw a profile of adenosine triphosphate (ATP) and to project its many actions...
Isoprenoids make up a remarkably diverse class of more than 25000 biomolecules that include familiar...
Protein kinases, representing one of the largest protein families involved in almost all aspects of ...
Adenosine triphosphate (ATP) is the main biological phosphoryl donor required in many enzymes includ...
Dihydroxyacetone kinases (DHAKs) catalyse the transfer of the phosphoryl group from adenosine tripho...
The catalytic mechanism that involves the cleavage of the phosphate diester model <b>BDNPP</b> (bis...
Fe3+, stabilised by the N7 group on adenine, interacts with the dianion of ADP, lowering the pKa of ...
Adenosine triphosphate (ATP) is the main biological phosphoryl donor required in many enzymes includ...
The mevalonate pathway is of important clinical, pharmaceutical, and biotechnological relevance. How...
Mevalonate pathway is of important clinical, pharmaceutical and biotechnological relevance.However, ...
Mevalonate Kinase (MVK) catalyses the ATP-Mg2+ mediated phosphate transfer of mevalonate to produce ...
Phosphate transfer reactions are catalyzed by a large number of enzymes comprising kinases, mutases ...
Protein kinases, representing one of the largest protein families involved in almost all aspects of ...
AbstractBackground: Phosphoryl transfer, typically involving high energy phosphate donors such as AT...
Isoprenoids make up a remarkably diverse class of more than 25000 biomolecules that include familiar...
An attempt is made to draw a profile of adenosine triphosphate (ATP) and to project its many actions...
Isoprenoids make up a remarkably diverse class of more than 25000 biomolecules that include familiar...
Protein kinases, representing one of the largest protein families involved in almost all aspects of ...
Adenosine triphosphate (ATP) is the main biological phosphoryl donor required in many enzymes includ...
Dihydroxyacetone kinases (DHAKs) catalyse the transfer of the phosphoryl group from adenosine tripho...
The catalytic mechanism that involves the cleavage of the phosphate diester model <b>BDNPP</b> (bis...
Fe3+, stabilised by the N7 group on adenine, interacts with the dianion of ADP, lowering the pKa of ...
Adenosine triphosphate (ATP) is the main biological phosphoryl donor required in many enzymes includ...
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