Additional file 5: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Additional file 5: of Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts

Yuan Zhou (179597)
Haozhen Ren (6161354)
Bo Dai (448609)
Jun Li (6494)
Longcheng Shang (6161357)
Jianfei Huang (317892)
Xiaolei Shi (319891)

December 2018

Figure S4. Tumor-derived exosomes activated HSCs in vivo. a Immunohistochemistry imaging of Ki67 sho...

Additional file 6: of CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110Î˛ and predicts poor prognosis

Xiao-Lu Ma (4175050)
Min-Na Shen (6578531)
Bo Hu (126105)
Bei-Li Wang (6578534)
Wen-Jing Yang (6578537)
Li-Hua Lv (6578540)
Hao Wang (39217)
Yan Zhou (6523)
An-Li Jin (6578543)
Yun-Fan Sun (6578546)
Chuan-Yan Zhang (6578549)
Shuang-Jian Qiu (157512)
Bai-Shen Pan (4175047)
Jian Zhou (28020)
Jia Fan (178422)
Xin-Rong Yang (202583)
Wei Guo (86150)

April 2019

Figure S5. In vivo function of CD73 in HCC. (A) Representative IHC images of PCNA expression level i...

Additional file 6: of Agonist redirected checkpoint, PD1-Fc-OX40L, for cancer immunotherapy

George Fromm (561951)
Suresh de Silva (166654)
Kellsey Johannes (6100478)
Arpita Patel (6100484)
Josiah Hornblower (6100490)
Taylor Schreiber (6100496)

December 2018

Figure S6. Mouse PD1-Fc-OX40L efficacy Âą CD4/CD8 depletion in CT26 tumor model and schematics of tu...

Additional file 6: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Figure S5. The expression of immune checkpoints on adoptively transferred TAA-specific CD8+ T cells....

Additional file 4: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Figure S3. The expression of immune checkpoints on CD8+ T cells and CD4â+âT cells from mice rece...

Additional file 3: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Figure S2. Characterization of OVA257-264-specific CTLs in HCC tumor microenvironment. (PDF 367 kb

Additional file 1: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Table S1. List of antibodies used in immunohistochemistry and in flow cytometry. (PDF 37 kb

Additional file 1: of Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background

Sook Chung (3425123)
Hyuk Moon (3425129)
Dae Kim (305795)
Kyung Cho (3425117)
Hye-Lim Ju (395738)
Do Kim (3425114)
Sang Ahn (3425126)
Kwang-Hyub Han (131978)
Simon Ro (3425120)

January 2016

Histological analysis of livers harvested at 15 days post hydrodynamic transfection with transposons...

Additional file 1: of Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen

Stefanie Wculek (6566330)
JoaquĂn Amores-Iniesta (6566342)
Ruth Conde-Garrosa (6566336)
SofĂa Khouili (6566345)
Ignacio Melero (81908)
David Sancho (5117801)

April 2019

Figure S1. Isolation and phenotypic analysis of cDC1s from the spleen of FLT3L-expressing B16 tumor-...

Additional file 1: of Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer

May Saung (5961734)
Stephen Muth (5961737)
Ding Ding (346784)
Dwayne Thomas (5961740)
Alex Blair (5961743)
Takahiro Tsujikawa (5809061)
Lisa Coussens (714916)
Elizabeth Jaffee (2029204)
Lei Zheng (106363)

November 2018

Figure S1. PD-1 expression on CD4+ and CD8+ T-cells can increase with the addition of αCSF-1R to GVA...

Additional file 1: of Human liver stem cells attenuate concanavalin A-induced acute liver injury by modulating myeloid-derived suppressor cells and CD4+ T cells in mice

Yanzhen Bi (6200753)
Jiannan Li (1505440)
Yonghong Yang (428510)
Quanyi Wang (296707)
Quanquan Wang (3196311)
Xiaobei Zhang (4730490)
Guanjun Dong (5966684)
Yibo Wang (304377)
Zhongping Duan (304742)
Zhenfeng Shu (6200756)
Tongjun Liu (449137)
Yu Chen (29959)
Kai Zhang (102844)
Feng Hong (174976)

January 2019

Biochemical evaluation in the serum and the detection of tracing of transplanted cells. Supplementar...

Additional file 1 of Phosphorylation of NF-κBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target

Xuan Xu (781842)
Yiming Lei (4006181)
Lingjun Chen (10666385)
Haoxiong Zhou (10666388)
Huiling Liu (481477)
Jie Jiang (187037)
Yidong Yang (2089252)
Bin Wu (138543)

August 2021

Additional file 1: Figure S1. Deficiency of hepatocytes p65 attenuated hepatocellular carcinogenesis...

Additional file 1: of STAT3-blocked whole-cell hepatoma vaccine induces cellular and humoral immune response against HCC

Qiuju Han (338057)
Yaqun Wang (149208)
Min Pang (634565)
Jian Zhang (1682)

November 2017

Table S1.The tumor formation rate in mice immunized with HCC-vaccine. Figure S2. HCC-vaccine can act...

Additional file 5: Figure S5. of Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet

Danielle Lussier (3493634)
Eric Woolf (3493631)
John Johnson (276810)
Kenneth Brooks (1890190)
Joseph Blattman (3493637)
Adrienne Scheck (315941)

May 2016

Gating strategies for cytokine expression of CD8+ T cells. Tumor-infiltrating lymphocytes (TILs) iso...

Additional file 2: of Vascular disruptive agent OXi4503 and anti-angiogenic agent Sunitinib combination treatment prolong survival of mice with CRC liver metastasis

Linh Nguyen (3436241)
Theodora Fifis (3483536)
Christopher Christophi (3483533)

July 2016

OXi4503, Sunitinib and combination treatments induce EMT in the surviving tumor cells. Formalin-fixe...

Additional file 5: of Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts

Yuan Zhou (179597)
Haozhen Ren (6161354)
Bo Dai (448609)
Jun Li (6494)
Longcheng Shang (6161357)
Jianfei Huang (317892)
Xiaolei Shi (319891)

December 2018

Figure S4. Tumor-derived exosomes activated HSCs in vivo. a Immunohistochemistry imaging of Ki67 sho...

Additional file 6: of CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110Î˛ and predicts poor prognosis

Xiao-Lu Ma (4175050)
Min-Na Shen (6578531)
Bo Hu (126105)
Bei-Li Wang (6578534)
Wen-Jing Yang (6578537)
Li-Hua Lv (6578540)
Hao Wang (39217)
Yan Zhou (6523)
An-Li Jin (6578543)
Yun-Fan Sun (6578546)
Chuan-Yan Zhang (6578549)
Shuang-Jian Qiu (157512)
Bai-Shen Pan (4175047)
Jian Zhou (28020)
Jia Fan (178422)
Xin-Rong Yang (202583)
Wei Guo (86150)

April 2019

Figure S5. In vivo function of CD73 in HCC. (A) Representative IHC images of PCNA expression level i...

Additional file 6: of Agonist redirected checkpoint, PD1-Fc-OX40L, for cancer immunotherapy

George Fromm (561951)
Suresh de Silva (166654)
Kellsey Johannes (6100478)
Arpita Patel (6100484)
Josiah Hornblower (6100490)
Taylor Schreiber (6100496)

December 2018

Figure S6. Mouse PD1-Fc-OX40L efficacy Âą CD4/CD8 depletion in CT26 tumor model and schematics of tu...

Additional file 6: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Figure S5. The expression of immune checkpoints on adoptively transferred TAA-specific CD8+ T cells....

Additional file 4: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Figure S3. The expression of immune checkpoints on CD8+ T cells and CD4â+âT cells from mice rece...

Additional file 3: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Figure S2. Characterization of OVA257-264-specific CTLs in HCC tumor microenvironment. (PDF 367 kb

Additional file 1: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Table S1. List of antibodies used in immunohistochemistry and in flow cytometry. (PDF 37 kb

Additional file 1: of Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background

Sook Chung (3425123)
Hyuk Moon (3425129)
Dae Kim (305795)
Kyung Cho (3425117)
Hye-Lim Ju (395738)
Do Kim (3425114)
Sang Ahn (3425126)
Kwang-Hyub Han (131978)
Simon Ro (3425120)

January 2016

Histological analysis of livers harvested at 15 days post hydrodynamic transfection with transposons...

Additional file 1: of Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen

Stefanie Wculek (6566330)
JoaquĂn Amores-Iniesta (6566342)
Ruth Conde-Garrosa (6566336)
SofĂa Khouili (6566345)
Ignacio Melero (81908)
David Sancho (5117801)

April 2019

Figure S1. Isolation and phenotypic analysis of cDC1s from the spleen of FLT3L-expressing B16 tumor-...

Additional file 1: of Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer

May Saung (5961734)
Stephen Muth (5961737)
Ding Ding (346784)
Dwayne Thomas (5961740)
Alex Blair (5961743)
Takahiro Tsujikawa (5809061)
Lisa Coussens (714916)
Elizabeth Jaffee (2029204)
Lei Zheng (106363)

November 2018

Figure S1. PD-1 expression on CD4+ and CD8+ T-cells can increase with the addition of αCSF-1R to GVA...

Additional file 1: of Human liver stem cells attenuate concanavalin A-induced acute liver injury by modulating myeloid-derived suppressor cells and CD4+ T cells in mice

Yanzhen Bi (6200753)
Jiannan Li (1505440)
Yonghong Yang (428510)
Quanyi Wang (296707)
Quanquan Wang (3196311)
Xiaobei Zhang (4730490)
Guanjun Dong (5966684)
Yibo Wang (304377)
Zhongping Duan (304742)
Zhenfeng Shu (6200756)
Tongjun Liu (449137)
Yu Chen (29959)
Kai Zhang (102844)
Feng Hong (174976)

January 2019

Biochemical evaluation in the serum and the detection of tracing of transplanted cells. Supplementar...

Additional file 1 of Phosphorylation of NF-κBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target

Xuan Xu (781842)
Yiming Lei (4006181)
Lingjun Chen (10666385)
Haoxiong Zhou (10666388)
Huiling Liu (481477)
Jie Jiang (187037)
Yidong Yang (2089252)
Bin Wu (138543)

August 2021

Additional file 1: Figure S1. Deficiency of hepatocytes p65 attenuated hepatocellular carcinogenesis...

Additional file 1: of STAT3-blocked whole-cell hepatoma vaccine induces cellular and humoral immune response against HCC

Qiuju Han (338057)
Yaqun Wang (149208)
Min Pang (634565)
Jian Zhang (1682)

November 2017

Table S1.The tumor formation rate in mice immunized with HCC-vaccine. Figure S2. HCC-vaccine can act...

Additional file 5: Figure S5. of Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet

Danielle Lussier (3493634)
Eric Woolf (3493631)
John Johnson (276810)
Kenneth Brooks (1890190)
Joseph Blattman (3493637)
Adrienne Scheck (315941)

May 2016

Gating strategies for cytokine expression of CD8+ T cells. Tumor-infiltrating lymphocytes (TILs) iso...

Additional file 2: of Vascular disruptive agent OXi4503 and anti-angiogenic agent Sunitinib combination treatment prolong survival of mice with CRC liver metastasis

Linh Nguyen (3436241)
Theodora Fifis (3483536)
Christopher Christophi (3483533)

July 2016

OXi4503, Sunitinib and combination treatments induce EMT in the surviving tumor cells. Formalin-fixe...

Additional file 5: of Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts

Yuan Zhou (179597)
Haozhen Ren (6161354)
Bo Dai (448609)
Jun Li (6494)
Longcheng Shang (6161357)
Jianfei Huang (317892)
Xiaolei Shi (319891)

December 2018

Figure S4. Tumor-derived exosomes activated HSCs in vivo. a Immunohistochemistry imaging of Ki67 sho...

Additional file 6: of CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110Î˛ and predicts poor prognosis

Xiao-Lu Ma (4175050)
Min-Na Shen (6578531)
Bo Hu (126105)
Bei-Li Wang (6578534)
Wen-Jing Yang (6578537)
Li-Hua Lv (6578540)
Hao Wang (39217)
Yan Zhou (6523)
An-Li Jin (6578543)
Yun-Fan Sun (6578546)
Chuan-Yan Zhang (6578549)
Shuang-Jian Qiu (157512)
Bai-Shen Pan (4175047)
Jian Zhou (28020)
Jia Fan (178422)
Xin-Rong Yang (202583)
Wei Guo (86150)

April 2019

Figure S5. In vivo function of CD73 in HCC. (A) Representative IHC images of PCNA expression level i...

Additional file 6: of Agonist redirected checkpoint, PD1-Fc-OX40L, for cancer immunotherapy

George Fromm (561951)
Suresh de Silva (166654)
Kellsey Johannes (6100478)
Arpita Patel (6100484)
Josiah Hornblower (6100490)
Taylor Schreiber (6100496)

December 2018

Figure S6. Mouse PD1-Fc-OX40L efficacy Âą CD4/CD8 depletion in CT26 tumor model and schematics of tu...

Additional file 5: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Abstract

Extracted data

Additional file 5: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Abstract

Extracted data

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