Herein a simple, catalyst- and solvent-free system for highly atom-economic synthesis of phthalazinones has been developed using phthalaldehydic acid, 2-acyl-benzoic acid, and substituted hydrazine as simple substrates. The reaction time was shortened to 20–60 min. Structurally diverse phthalaldehydic acids, 2-acyl-benzoic acids, and hydrazines were transformed into phthalazinones with a nearly 100% yield regardless of the aggregate state and electronic nature of the substituents. The transformation was demonstrated to be amenable for scale-up with multiple liquid and solid materials. In addition, isolation and purification of the crude products can be simply done with only crystallization. The heavy metal pollution was also eliminated from...
A sequential one‐pot strategy for the diversified synthesis of phthalazines, phthalazinones and benz...
2-Amino-2-(aroylhydrazono)ethyl aryl ethers, readily obtained from a wide range of aryloxyacetonitri...
Azines, pyrazoles, and pyridazinones were isolated as the sole products in high yields (>97%) by ...
A simple one-pot, two-step process for the conversion of 2-acylbenzoic acids to phthalazin-1(2<i>H<...
A palladium-catalyzed one-pot synthesis of phthalazinones from 2-halomethyl benzoates, paraformaldeh...
843-851An efficient and convenient zinc acetate dihydrate (Zn(OAc)2.2H2O) catalyzed synthesis of 1H-...
International audienceA series of hydrazones, as potential therapeutic agents, were successfully syn...
A simple versatile method for the conversion of 1-aroyl-2-( substituted benzylidene)-hydrazines to 1...
Boron sulfonic acid was applied as an efficient heterogeneous and reusable catalyst for the synthesi...
A novel strategy for the construction of the phthalazin-1(2H)-one scaffold has been developed by mea...
1462-1467A high yielding and environmentally benign synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,...
Bovine Serum Albumin (BSA) was used as a green, inexpensive and efficient biocatalyst, for synthesis...
AbstractA simple one-pot, water-mediated synthetic method for the preparation of 2-(substituted phen...
A controlled tandem synthetic route to azines from various alcohols and hydrazine hydrate by the use...
<p>In this paper, C–N bond formation between 2,3-dihydrophthalazine-1(4<i>H</i>),4-dione (phthalhydr...
A sequential one‐pot strategy for the diversified synthesis of phthalazines, phthalazinones and benz...
2-Amino-2-(aroylhydrazono)ethyl aryl ethers, readily obtained from a wide range of aryloxyacetonitri...
Azines, pyrazoles, and pyridazinones were isolated as the sole products in high yields (>97%) by ...
A simple one-pot, two-step process for the conversion of 2-acylbenzoic acids to phthalazin-1(2<i>H<...
A palladium-catalyzed one-pot synthesis of phthalazinones from 2-halomethyl benzoates, paraformaldeh...
843-851An efficient and convenient zinc acetate dihydrate (Zn(OAc)2.2H2O) catalyzed synthesis of 1H-...
International audienceA series of hydrazones, as potential therapeutic agents, were successfully syn...
A simple versatile method for the conversion of 1-aroyl-2-( substituted benzylidene)-hydrazines to 1...
Boron sulfonic acid was applied as an efficient heterogeneous and reusable catalyst for the synthesi...
A novel strategy for the construction of the phthalazin-1(2H)-one scaffold has been developed by mea...
1462-1467A high yielding and environmentally benign synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,...
Bovine Serum Albumin (BSA) was used as a green, inexpensive and efficient biocatalyst, for synthesis...
AbstractA simple one-pot, water-mediated synthetic method for the preparation of 2-(substituted phen...
A controlled tandem synthetic route to azines from various alcohols and hydrazine hydrate by the use...
<p>In this paper, C–N bond formation between 2,3-dihydrophthalazine-1(4<i>H</i>),4-dione (phthalhydr...
A sequential one‐pot strategy for the diversified synthesis of phthalazines, phthalazinones and benz...
2-Amino-2-(aroylhydrazono)ethyl aryl ethers, readily obtained from a wide range of aryloxyacetonitri...
Azines, pyrazoles, and pyridazinones were isolated as the sole products in high yields (>97%) by ...