Bone metastases analysis.
- Valerie De Meulenaere (6065855)
- Sara Neyt (849156)
- Bert Vandeghinste (428996)
- Pieter Mollet (6065858)
- Olivier De Wever (125422)
- Elke Decrock (452224)
- Luc Leybaert (313676)
- Ingeborg Goethals (849158)
- Christian Vanhove (772792)
- Benedicte Descamps (772793)
- Karel Deblaere (3079569)
Publication date
December 2018
DOI Publisher
Public Library of Science (PLoS)Abstract
a-d. High-resolution μCT images acquired on X-CUBE (recon: FDK—50 μm). Evaluation showed metastasis throughout the skeleton in 81% (17/21) of the rats. Examples of lytic bone lesions detected in vertebra (a), tibia (b), femur (c) and skull (d) are indicated with an arrow. e-f. Static full-body [18F]FDG PET image showing metastasis in the skeleton of rat (e) and no metastasis in the skeleton of mouse (f). g. Number of metastasis affected bones showing a significant difference between rats and mice. h. Kaplan Meier curves and log-rank test demonstrate a significant difference in clinical symptoms free survival times between rats and mice.</p
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