Widespread seasonal sensitive comorbid diseases.

(a) Seasonal Mann-Kendall p-values of seasonal sensitive life style diseases represented as heat map for the entire period (Jan 2004 to Dec 2016). The hierarchical clustering clearly divided them into diseases with (red box) and without (blue box) season trend. (b) Shape based distance matrix scores among the major highly comorbid diseases of high altitude represented as heat map for the entire period (Jan 2004 to Dec 2016). The hierarchical clustering clearly divided them into diseases with (red box) and without (blue box) seasonal pattern matching. Please note that the four diseases (obesity, asthma, hypertension, and fibrosis) in the red boxes have similar seasonal trends and seasonal patterns named as “Group1” diseases (S1 Table).