Volcano plot of differential expression between the 5,000 m site and the two lower-elevation sites.

Each point is a transcript. The x-axis is the beta value which is the natural log of the fold difference and the y-axis is the–log10(qval). The q-value is the multiple test corrected p-value. Colored points are significantly differentially expressed between the high-elevation group and the other locations at a q-value of < 0.05. Transcripts falling above zero on the x-axis (green) are upregulated in the 5,000 m samples and transcripts falling below zero (blue) are down-regulated. Transcripts driving the enrichment of the OXPHOS pathway are shown in dark green circles. Transcripts identified in the text to be of particular interest based on our literature search are also shown with a dark green or dark blue point, with different shapes indicating what each gene is related to.