Additional file 13: of Inherited and multiple de novo mutations in autism/developmental delay risk genes suggest a multifactorial model
- Hui Guo (110581)
- Tianyun Wang (2884355)
- Huidan Wu (6084857)
- Min Long (397430)
- Bradley Coe (6084860)
- Honghui Li (383749)
- Guanglei Xun (4776639)
- Jianjun Ou (703720)
- Biyuan Chen (6084863)
- Guiqin Duan (6084866)
- Ting Bai (92170)
- Ningxia Zhao (6084869)
- Yidong Shen (172967)
- Yun Li (692280)
- Yazhe Wang (1742299)
- Yu Zhang (12946)
- Carl Baker (196947)
- Yanling Liu (218474)
- Nan Pang (5181971)
- Lian Huang (1889359)
- Lin Han (113452)
- Xiangbin Jia (6084872)
- Cenying Liu (6084875)
- Hailun Ni (6084878)
- Xinyi Yang (324560)
- Lu Xia (1509745)
- Jingjing Chen (293564)
- Lu Shen (161789)
- Ying Li (38224)
- Rongjuan Zhao (6084881)
- Wenjing Zhao (318619)
- Jing Peng (102796)
- Qian Pan (77107)
- Zhigao Long (3623711)
- Wei Su (89824)
- Jieqiong Tan (180436)
- Xiaogang Du (745028)
- Xiaoyan Ke (303580)
- Meiling Yao (160516)
- Zhengmao Hu (490757)
- Xiaobing Zou (5454998)
- Jingping Zhao (151214)
- Raphael Bernier (196963)
- Evan Eichler (3629480)
- Kun Xia (9853)
DOIAbstract
Figure S8. Multiple-hit model for ASD excluding DNM cases. Shown are comparisons of autism probands and unaffected siblings with one or more DNM. Logistic histograms compare residual DNM counts (DNM number residuals, note: after correction, a residual of 0 does not represent a count of 0) adjusted for the father’s age at birth and gender, and the probability of being a proband or unaffected sibling. This analysis demonstrates an increased burden of multiple hits among affected individuals (OR = 1.15, p = 0.0278) (a). When samples are stratified by genetic sex, we observe a slight increase but no significant effect among males (OR = 1.09, p = 0.6) (b), while females demonstrate a stronger (OR = 1.3, p = 0.037) (c) effect than the grouped ana...
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