Threshold for Unacceptable Risk of Non-Adherence (TURN) and prescription volume for 112 drug-indication groups.

TURN* corresponds to the frequency of missing doses above which 75% of physicians’ estimates were located for each drug-indication group. Results with alternative cut-offs are detailed in S2 Table. Each drug-indication group is plotted as a rectangle: 1) rectangle color corresponds to the TURN*; 2) rectangle area size is proportional to the number of pill boxes reimbursed in 2016 in France (according to the French national health insurance database). We summed the number of pill boxes for the medications belonging to each group. In case of several therapeutic indications for a same medication, we divided the number of pill boxes by the number of indications. Abbreviations: ACE: angiotensin-converting enzyme, ARBs: angiotensin receptor blockers, CCBs: calcium channel blockers; COPD: Chronic Obstructive Pulmonary Disease; GORD: gastro-oesophageal reflux diseases; HBP: high blood pressure; NSAIDs: non-steroidal anti-inflammatory drugs, MI: myocardial infarction.