Correlation between gemcitabine chemosensitivity and basal expression of hENT1 mRNA.

The contribution of DNA replication stress marked by high-intensity, pan-nuclear γH2AX staining to chemosensitization by CHK1 and WEE1 inhibitors

Leslie A. Parsels (1910506)
Joshua D. Parsels (1910512)
Daria M. Tanska (1910503)
Jonathan Maybaum (1910515)
Theodore S. Lawrence (235458)
Meredith A. Morgan (818464)

June 2018

Small molecule inhibitors of the checkpoint proteins CHK1 and WEE1 are currently in clinical deve...

Human equilibrative nucleoside transporter 1 (hENT1) levels predict response to gemcitabine in patients with biliary tract cancer (BTC)

Santini D.
Schiavon G.
Vincenzi B.
Cass C.
Vasile E.
Manazza A.
Catalano V.
Baldi G.
Rizzo S.
Giacobino A.
Chiusa L.
Caraglia M.
Russo A.
Mackey J.
Falcone A.
Tonini G.
LAI, ROBERTO

January 2011

Background and aim: Translational data suggest that nucleoside transporters, in particular human equ...

Profiling the transcriptional and epigenomic response to gemcitabine.

Oana Ursu (4509544)
Sara J. C. Gosline (222488)
Neil Beeharry (154698)
Lauren Fink (4509547)
Vikram Bhattacharjee (1687687)
Shao-shan Carol Huang (280252)
Yan Zhou (6523)
Tim Yen (222064)
Ernest Fraenkel (16296)

October 2017

We measured changes in gene expression upon treatment of PANC1 cells with gemcitabine by RNA-seq....

Effects of hENT1 siRNA on gemcitabine sensitivity.

Jaihwan Kim (481708)
Haeryoung Kim (3692143)
Jong-chan Lee (6091127)
Jin Won Kim (224828)
Woo Hyun Paik (481705)
Sang Hyub Lee (5047862)
Jin-Hyeok Hwang (249030)
Ji Kon Ryu (481706)
Yong-Tae Kim (249037)

December 2018

During incubation with gemcitabine, cell proliferation at 144 h after treatment with hENT1 siRNA was...

Human equilibrative nucleoside transporter 1 (hENT1) expression as a predictive biomarker for gemcitabine chemotherapy in biliary tract cancer

Jaihwan Kim (481708)
Haeryoung Kim (3692143)
Jong-chan Lee (6091127)
Jin Won Kim (224828)
Woo Hyun Paik (481705)
Sang Hyub Lee (5047862)
Jin-Hyeok Hwang (249030)
Ji Kon Ryu (481706)
Yong-Tae Kim (249037)

December 2018

Gemcitabine is a principal chemotherapeutic agent for biliary tract cancer (BTC). Expression of huma...

Half-maximal inhibitory concentration (IC50) of gemcitabine in four biliary tract cancer (BTC) cell lines.

Jaihwan Kim (481708)
Haeryoung Kim (3692143)
Jong-chan Lee (6091127)
Jin Won Kim (224828)
Woo Hyun Paik (481705)
Sang Hyub Lee (5047862)
Jin-Hyeok Hwang (249030)
Ji Kon Ryu (481706)
Yong-Tae Kim (249037)

December 2018

Half-maximal inhibitory concentration (IC50) of gemcitabine in four biliary tract cancer (BTC) cell ...

Human equilibrative nucleoside transporter 1 (hENT1) expression as a predictive biomarker for gemcitabine chemotherapy in biliary tract cancer.

Jaihwan Kim
Haeryoung Kim
Jong-Chan Lee
Jin Won Kim
Woo Hyun Paik
Sang Hyub Lee
Jin-Hyeok Hwang
Ji Kon Ryu
Yong-Tae Kim

January 2018

Gemcitabine is a principal chemotherapeutic agent for biliary tract cancer (BTC). Expression of huma...

Effects of hENT1 siRNA on sensitivity of BTC cells to gemcitabine.

Jaihwan Kim (481708)
Haeryoung Kim (3692143)
Jong-chan Lee (6091127)
Jin Won Kim (224828)
Woo Hyun Paik (481705)
Sang Hyub Lee (5047862)
Jin-Hyeok Hwang (249030)
Ji Kon Ryu (481706)
Yong-Tae Kim (249037)

December 2018

Pretreatment with hENT1 siRNA was conducted to assess the effect of the hENT1 knockdown on gemcitabi...

Gemcitabine sensitivity in cervical cancer cells and basal gene expression.

Myrna Candelaria (4657)
Erick de la Cruz-Hernandez (5652481)
Lucia Taja-Chayeb (42946)
Enrique Perez-Cardenas (5652484)
Catalina Trejo-Becerril (42944)
Aurora Gonzalez-Fierro (4655)
Alma Chavez-Blanco (4653)
Ernesto Soto-Reyes (329632)
Guadalupe Dominguez (329633)
Jaenai E. Trujillo (329635)
Jose Diaz-Chavez (80713)
Alfonso Duenas-Gonzalez (5652487)

February 2013

A. The IC50 of gemcitabine for HeLa, CaLo, SiHa and C33A cells were 3.3 µM, 0.3 µM, >1...

The correlation between gemcitabine efficacy and the ratio of dCK and RR.

Ozan Kahramanoğullari (112379)
Gianluca Fantaccini (112384)
Paola Lecca (112388)
Daniele Morpurgo (112392)
Corrado Priami (112396)

December 2012

The correlation between gemcitabine efficacy, measured as and the ratio of dCK and RR concentrat...

Human equilibrative nucleoside transporter 1 (hENT1) expression as a predictive biomarker for gemcitabine chemotherapy in biliary tract cancer - Fig 6

Jaihwan Kim (481708)
Haeryoung Kim (3692143)
Jong-chan Lee (6091127)
Jin Won Kim (224828)
Woo Hyun Paik (481705)
Sang Hyub Lee (5047862)
Jin-Hyeok Hwang (249030)
Ji Kon Ryu (481706)
Yong-Tae Kim (249037)

December 2018

(A) Median progression-free survival (PFS) of patients administered gemcitabine and cisplatin combin...

hENT1 expression is predictive of gemcitabine outcome in pancreatic cancer: A systematic review.

Nordh, Stina
Ansari, Daniel
Andersson, Roland

January 2014

High human equilibrative nucleoside transporter 1 (hENT1)-expression has shown a survival benefit in...

Inhibition of cytidine deaminase (CDA) contributes to improved gemcitabine sensitivity.

Naotake Funamizu (182388)
Curtis Ray Lacy (323133)
Kaori Fujita (323134)
Kenei Furukawa (323135)
Takeyuki Misawa (323136)
Katsuhiko Yanaga (323137)
Yoshinobu Manome (323139)

February 2013

A. Levels of CDA mRNA in pancreatic and lung carcinoma cell lines were evaluated by real-t...

Gene expression analysis in response to gemcitabine and combined treatment.

Foong Ying Wong (114500)
Natalia Liem (114504)
Chen Xie (114508)
Fui Leng Yan (114512)
Wing Cheong Wong (114515)
Lingzhi Wang (114519)
Wei-Peng Yong (114522)

December 2012

Heatmap of 2702 significant differentially expressed genes in gemcitabine resistant, GEM-R and ge...

hENT1 Predicts Benefit from Gemcitabine in Pancreatic Cancer but Only with Low CDA mRNA.

Aughton, K
Elander, NO
Evans, A
Jackson, R
Campbell, F
Costello, E
Halloran, CM
Mackey, JR
Scarfe, AG
Valle, JW
Carter, R
Cunningham, D
Tebbutt, NC
Goldstein, D
Shannon, J
Glimelius, B
Hackert, T
Charnley, RM
Anthoney, A
Lerch, MM
Mayerle, J
Palmer, DH
Büchler, MW
Ghaneh, P
Neoptolemos, JP
Greenhalf, W

November 2021

Gemcitabine or 5-fluorouracil (5-FU) based treatments can be selected for pancreatic cancer. Equilib...

The contribution of DNA replication stress marked by high-intensity, pan-nuclear γH2AX staining to chemosensitization by CHK1 and WEE1 inhibitors

Leslie A. Parsels (1910506)
Joshua D. Parsels (1910512)
Daria M. Tanska (1910503)
Jonathan Maybaum (1910515)
Theodore S. Lawrence (235458)
Meredith A. Morgan (818464)

June 2018

Small molecule inhibitors of the checkpoint proteins CHK1 and WEE1 are currently in clinical deve...

Human equilibrative nucleoside transporter 1 (hENT1) levels predict response to gemcitabine in patients with biliary tract cancer (BTC)

Santini D.
Schiavon G.
Vincenzi B.
Cass C.
Vasile E.
Manazza A.
Catalano V.
Baldi G.
Rizzo S.
Giacobino A.
Chiusa L.
Caraglia M.
Russo A.
Mackey J.
Falcone A.
Tonini G.
LAI, ROBERTO

January 2011

Background and aim: Translational data suggest that nucleoside transporters, in particular human equ...

Profiling the transcriptional and epigenomic response to gemcitabine.

Oana Ursu (4509544)
Sara J. C. Gosline (222488)
Neil Beeharry (154698)
Lauren Fink (4509547)
Vikram Bhattacharjee (1687687)
Shao-shan Carol Huang (280252)
Yan Zhou (6523)
Tim Yen (222064)
Ernest Fraenkel (16296)

October 2017

We measured changes in gene expression upon treatment of PANC1 cells with gemcitabine by RNA-seq....

Effects of hENT1 siRNA on gemcitabine sensitivity.

Jaihwan Kim (481708)
Haeryoung Kim (3692143)
Jong-chan Lee (6091127)
Jin Won Kim (224828)
Woo Hyun Paik (481705)
Sang Hyub Lee (5047862)
Jin-Hyeok Hwang (249030)
Ji Kon Ryu (481706)
Yong-Tae Kim (249037)

December 2018

During incubation with gemcitabine, cell proliferation at 144 h after treatment with hENT1 siRNA was...

Human equilibrative nucleoside transporter 1 (hENT1) expression as a predictive biomarker for gemcitabine chemotherapy in biliary tract cancer

Jaihwan Kim (481708)
Haeryoung Kim (3692143)
Jong-chan Lee (6091127)
Jin Won Kim (224828)
Woo Hyun Paik (481705)
Sang Hyub Lee (5047862)
Jin-Hyeok Hwang (249030)
Ji Kon Ryu (481706)
Yong-Tae Kim (249037)

December 2018

Gemcitabine is a principal chemotherapeutic agent for biliary tract cancer (BTC). Expression of huma...

Half-maximal inhibitory concentration (IC50) of gemcitabine in four biliary tract cancer (BTC) cell lines.

Jaihwan Kim (481708)
Haeryoung Kim (3692143)
Jong-chan Lee (6091127)
Jin Won Kim (224828)
Woo Hyun Paik (481705)
Sang Hyub Lee (5047862)
Jin-Hyeok Hwang (249030)
Ji Kon Ryu (481706)
Yong-Tae Kim (249037)

December 2018

Half-maximal inhibitory concentration (IC50) of gemcitabine in four biliary tract cancer (BTC) cell ...

Human equilibrative nucleoside transporter 1 (hENT1) expression as a predictive biomarker for gemcitabine chemotherapy in biliary tract cancer.

Jaihwan Kim
Haeryoung Kim
Jong-Chan Lee
Jin Won Kim
Woo Hyun Paik
Sang Hyub Lee
Jin-Hyeok Hwang
Ji Kon Ryu
Yong-Tae Kim

January 2018

Gemcitabine is a principal chemotherapeutic agent for biliary tract cancer (BTC). Expression of huma...

Effects of hENT1 siRNA on sensitivity of BTC cells to gemcitabine.

Jaihwan Kim (481708)
Haeryoung Kim (3692143)
Jong-chan Lee (6091127)
Jin Won Kim (224828)
Woo Hyun Paik (481705)
Sang Hyub Lee (5047862)
Jin-Hyeok Hwang (249030)
Ji Kon Ryu (481706)
Yong-Tae Kim (249037)

December 2018

Pretreatment with hENT1 siRNA was conducted to assess the effect of the hENT1 knockdown on gemcitabi...

Gemcitabine sensitivity in cervical cancer cells and basal gene expression.

Myrna Candelaria (4657)
Erick de la Cruz-Hernandez (5652481)
Lucia Taja-Chayeb (42946)
Enrique Perez-Cardenas (5652484)
Catalina Trejo-Becerril (42944)
Aurora Gonzalez-Fierro (4655)
Alma Chavez-Blanco (4653)
Ernesto Soto-Reyes (329632)
Guadalupe Dominguez (329633)
Jaenai E. Trujillo (329635)
Jose Diaz-Chavez (80713)
Alfonso Duenas-Gonzalez (5652487)

February 2013

A. The IC50 of gemcitabine for HeLa, CaLo, SiHa and C33A cells were 3.3 µM, 0.3 µM, >1...

The correlation between gemcitabine efficacy and the ratio of dCK and RR.

Ozan Kahramanoğullari (112379)
Gianluca Fantaccini (112384)
Paola Lecca (112388)
Daniele Morpurgo (112392)
Corrado Priami (112396)

December 2012

The correlation between gemcitabine efficacy, measured as and the ratio of dCK and RR concentrat...

Human equilibrative nucleoside transporter 1 (hENT1) expression as a predictive biomarker for gemcitabine chemotherapy in biliary tract cancer - Fig 6

Jaihwan Kim (481708)
Haeryoung Kim (3692143)
Jong-chan Lee (6091127)
Jin Won Kim (224828)
Woo Hyun Paik (481705)
Sang Hyub Lee (5047862)
Jin-Hyeok Hwang (249030)
Ji Kon Ryu (481706)
Yong-Tae Kim (249037)

December 2018

(A) Median progression-free survival (PFS) of patients administered gemcitabine and cisplatin combin...

hENT1 expression is predictive of gemcitabine outcome in pancreatic cancer: A systematic review.

Nordh, Stina
Ansari, Daniel
Andersson, Roland

January 2014

High human equilibrative nucleoside transporter 1 (hENT1)-expression has shown a survival benefit in...

Inhibition of cytidine deaminase (CDA) contributes to improved gemcitabine sensitivity.

Naotake Funamizu (182388)
Curtis Ray Lacy (323133)
Kaori Fujita (323134)
Kenei Furukawa (323135)
Takeyuki Misawa (323136)
Katsuhiko Yanaga (323137)
Yoshinobu Manome (323139)

February 2013

A. Levels of CDA mRNA in pancreatic and lung carcinoma cell lines were evaluated by real-t...

Gene expression analysis in response to gemcitabine and combined treatment.

Foong Ying Wong (114500)
Natalia Liem (114504)
Chen Xie (114508)
Fui Leng Yan (114512)
Wing Cheong Wong (114515)
Lingzhi Wang (114519)
Wei-Peng Yong (114522)

December 2012

Heatmap of 2702 significant differentially expressed genes in gemcitabine resistant, GEM-R and ge...

hENT1 Predicts Benefit from Gemcitabine in Pancreatic Cancer but Only with Low CDA mRNA.

Aughton, K
Elander, NO
Evans, A
Jackson, R
Campbell, F
Costello, E
Halloran, CM
Mackey, JR
Scarfe, AG
Valle, JW
Carter, R
Cunningham, D
Tebbutt, NC
Goldstein, D
Shannon, J
Glimelius, B
Hackert, T
Charnley, RM
Anthoney, A
Lerch, MM
Mayerle, J
Palmer, DH
Büchler, MW
Ghaneh, P
Neoptolemos, JP
Greenhalf, W

November 2021

Gemcitabine or 5-fluorouracil (5-FU) based treatments can be selected for pancreatic cancer. Equilib...

The contribution of DNA replication stress marked by high-intensity, pan-nuclear γH2AX staining to chemosensitization by CHK1 and WEE1 inhibitors

Leslie A. Parsels (1910506)
Joshua D. Parsels (1910512)
Daria M. Tanska (1910503)
Jonathan Maybaum (1910515)
Theodore S. Lawrence (235458)
Meredith A. Morgan (818464)

June 2018

Small molecule inhibitors of the checkpoint proteins CHK1 and WEE1 are currently in clinical deve...

Human equilibrative nucleoside transporter 1 (hENT1) levels predict response to gemcitabine in patients with biliary tract cancer (BTC)

Santini D.
Schiavon G.
Vincenzi B.
Cass C.
Vasile E.
Manazza A.
Catalano V.
Baldi G.
Rizzo S.
Giacobino A.
Chiusa L.
Caraglia M.
Russo A.
Mackey J.
Falcone A.
Tonini G.
LAI, ROBERTO

January 2011

Background and aim: Translational data suggest that nucleoside transporters, in particular human equ...

Profiling the transcriptional and epigenomic response to gemcitabine.

Oana Ursu (4509544)
Sara J. C. Gosline (222488)
Neil Beeharry (154698)
Lauren Fink (4509547)
Vikram Bhattacharjee (1687687)
Shao-shan Carol Huang (280252)
Yan Zhou (6523)
Tim Yen (222064)
Ernest Fraenkel (16296)

October 2017

We measured changes in gene expression upon treatment of PANC1 cells with gemcitabine by RNA-seq....

Correlation between gemcitabine chemosensitivity and basal expression of <i>hENT1</i> mRNA.

Abstract

Extracted data

Correlation between gemcitabine chemosensitivity and basal expression of <i>hENT1</i> mRNA.

Abstract

Extracted data

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