Hypothesis for the endogenous PGD<sub>2</sub>-GPR44/DP2 axis mechanism of action in islets.
- Stanko Skrtic (707913)
- Björn Tyrberg (512660)
- Malin Broberg (6091460)
- Hans Ericsson (6091463)
- Volker Schnecke (5227136)
- Magnus Kjaer (6091466)
- Marcus Hompesch (622959)
- Eva-Marie Andersson (162285)
- Erik Ryberg (3394721)
- Alexander Aivazidis (6091469)
- Charlotte Wennberg Huldt (6091472)
- Lars Löfgren (5896730)
- Linda Morrow (546622)
- Joanna Parkinson (6091475)
- Tina Rydén-Bergsten (6091478)
- Elaine Watkins (6091481)
- Maria Sörhede Winzell (707911)
Publication date
December 2018
DOI Publisher
Public Library of Science (PLoS)Abstract
Glucose and IL-1beta induced PTGS2 (COX-2) expression in stellate cells which stimulates the production of PGD2 synthesis. PGD2 is secreted and may act in a paracrine fashion on GPR44/DP2 on beta-cells, inhibiting cAMP and thereby reducing GSIS.</p
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