Tissue expression of GPR44/DP2 and PGD₂ related genes and characterization of pancreatic stellate cells.

PTGDR2 (GPR44/DP2) mRNA expression in human beta-cells (Healthy, n = 197; T2DM, n = 112) (a) and pancreatic stellate cells (Healthy, n = 23; T2DM, n = 31) (b). Heat map of stellate cell signature gene expression sub-classified as quiescent, immune activated (imm) and standard activated (stand) stellate cells according to the description in the main text (c). Quantification of stellate cell subpopulations in healthy and T2D donor human islets (d). Expression of GPR44/DP2 and PGD2 related genes in subclasses of stellate cells (e). Data are presented as mean ± SEM (a-b), total number of cells (d), and individual cells (e). *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.