Background: Characterization of the intracellular biochemical processes that regulate the generation and maintenance of effector and memory CD8+ T-cells from naïve precursors is essential for our understanding of adaptive immune responses and the development of immunotherapies. However, the metabolic determinants of antigen-driven activation and differentiation remain poorly defined, especially in humans.Methods: We used a variety of different approaches, including gene expression profiling and measurements of nutrient flux, to characterize the basal and activation-induced energetic requirements of naïve and phenotypically-defined subsets of human memory CD8+ T-cells.Findings: Profound metabolic differences were apparent as a function of di...
Cytotoxic CD8 <sup>+</sup> T cells are a key element of the adaptative immune system to ...
<p>(A, B) Isolated CD4 and CD8 T cells were stimulated for 72 h on plates coated with high (10 µg/ml...
mTOR is a central integrator of metabolic and immunological stimuli, dictating immune cell activatio...
Background: Characterization of the intracellular biochemical processes that regulate the generation...
Background: Characterization of the intracellular biochemical processes that regulate the generation...
Background: Characterization of the intracellular biochemical processes that regulate the generation...
International audienceBackground: Characterization of the intracellular biochemical processes that r...
Background: Characterization of the intracellular biochemical processes that regulate the generation...
Naïve CD8+ T cells become activated if they recognize their specific antigen in the presence of co-s...
Background: Antigenic stimulation of the T cell receptor (TCR) initiates a change from a resting sta...
Immune cells employ a diverse array of metabolic programs upon stimulation that have far-reaching co...
In this study we examined the metabolic requirements of human T helper cells and the effect of manip...
Invariant natural killer T (iNKT) cells comprise a unique subset of lymphocytes that are primed for ...
Metabolic pathways that regulate T-cell function show promise as therapeutic targets in diverse dise...
Summary: T cells compete with malignant cells for limited nutrients within the solid tumor microenvi...
Cytotoxic CD8 <sup>+</sup> T cells are a key element of the adaptative immune system to ...
<p>(A, B) Isolated CD4 and CD8 T cells were stimulated for 72 h on plates coated with high (10 µg/ml...
mTOR is a central integrator of metabolic and immunological stimuli, dictating immune cell activatio...
Background: Characterization of the intracellular biochemical processes that regulate the generation...
Background: Characterization of the intracellular biochemical processes that regulate the generation...
Background: Characterization of the intracellular biochemical processes that regulate the generation...
International audienceBackground: Characterization of the intracellular biochemical processes that r...
Background: Characterization of the intracellular biochemical processes that regulate the generation...
Naïve CD8+ T cells become activated if they recognize their specific antigen in the presence of co-s...
Background: Antigenic stimulation of the T cell receptor (TCR) initiates a change from a resting sta...
Immune cells employ a diverse array of metabolic programs upon stimulation that have far-reaching co...
In this study we examined the metabolic requirements of human T helper cells and the effect of manip...
Invariant natural killer T (iNKT) cells comprise a unique subset of lymphocytes that are primed for ...
Metabolic pathways that regulate T-cell function show promise as therapeutic targets in diverse dise...
Summary: T cells compete with malignant cells for limited nutrients within the solid tumor microenvi...
Cytotoxic CD8 <sup>+</sup> T cells are a key element of the adaptative immune system to ...
<p>(A, B) Isolated CD4 and CD8 T cells were stimulated for 72 h on plates coated with high (10 µg/ml...
mTOR is a central integrator of metabolic and immunological stimuli, dictating immune cell activatio...