Time-dependent relative activation of nuclear Nrf2 in EGb761 treated cells normalized to untreated cells (control) of three independent experiments using the Nrf2 Transcription Factor Assay Kit (Colorimetric, Abcam) is demonstrated as means ± SD. *p<0.05, **p<0.01 analyzed by student’s t-test.</p
<p>(<b>A</b>) A549 cells were exposed to 12.5 µg/ml PCN for the indicated time intervals. NRF2 was p...
Environmental pollutants and toxicants expose cells to oxidative and electrophilic challenges. Oxida...
Nuclear factor E2-related factor 1 (Nrf1) is a basic leucine zipper transcription factor that plays ...
<p>A FACS: the average of the median signal intensities in cells stained with anti-NRF2 antibodies ...
<p>Asterisk (*) denotes statistical significance (p<0.05) compared to DMSO control (A) and non-expos...
<p>MEF cells were preincubated with 20 μM SP600125 for 1 h and treated with LG2055 for 24 h. (A) The...
<p>A. Pulse-chase assay was conducted with MDA-MB-231 cells transfected with either an empty vector ...
<p>(A-D) MEF cells were cultured with or without LG2055 for 24 h. (A, D) The total cell lysates were...
A) Under normal conditions NRF2 is kept at low steady state levels in the cytoplasm, a process which...
<p>NF-kB (A) was analyzed as described in materials and methods; Nrf2 mRNA (A) was analyzed by quant...
<p>(A, B) MEF cells were preincubated with 20 μM U0126 for 1 h and treated with LG2055 for 24 h. (A)...
BM-MNCs were treated for 4h with DSBA at increasing concentrations from 5 to 20 μM and levels of Nrf...
<p>(A) AGS cells were treated with DAS, DADS, and DATS (20 µM of each). After 1 h, the cells were ha...
The transcription factor nuclear factor κB (NF-κB) or other components of this pathway have been id...
<p>Top, EMSA autoradiography of NF-κB DNA binding activity. Lane 1, control; lane 2, SAH; lane 3, SA...
<p>(<b>A</b>) A549 cells were exposed to 12.5 µg/ml PCN for the indicated time intervals. NRF2 was p...
Environmental pollutants and toxicants expose cells to oxidative and electrophilic challenges. Oxida...
Nuclear factor E2-related factor 1 (Nrf1) is a basic leucine zipper transcription factor that plays ...
<p>A FACS: the average of the median signal intensities in cells stained with anti-NRF2 antibodies ...
<p>Asterisk (*) denotes statistical significance (p<0.05) compared to DMSO control (A) and non-expos...
<p>MEF cells were preincubated with 20 μM SP600125 for 1 h and treated with LG2055 for 24 h. (A) The...
<p>A. Pulse-chase assay was conducted with MDA-MB-231 cells transfected with either an empty vector ...
<p>(A-D) MEF cells were cultured with or without LG2055 for 24 h. (A, D) The total cell lysates were...
A) Under normal conditions NRF2 is kept at low steady state levels in the cytoplasm, a process which...
<p>NF-kB (A) was analyzed as described in materials and methods; Nrf2 mRNA (A) was analyzed by quant...
<p>(A, B) MEF cells were preincubated with 20 μM U0126 for 1 h and treated with LG2055 for 24 h. (A)...
BM-MNCs were treated for 4h with DSBA at increasing concentrations from 5 to 20 μM and levels of Nrf...
<p>(A) AGS cells were treated with DAS, DADS, and DATS (20 µM of each). After 1 h, the cells were ha...
The transcription factor nuclear factor κB (NF-κB) or other components of this pathway have been id...
<p>Top, EMSA autoradiography of NF-κB DNA binding activity. Lane 1, control; lane 2, SAH; lane 3, SA...
<p>(<b>A</b>) A549 cells were exposed to 12.5 µg/ml PCN for the indicated time intervals. NRF2 was p...
Environmental pollutants and toxicants expose cells to oxidative and electrophilic challenges. Oxida...
Nuclear factor E2-related factor 1 (Nrf1) is a basic leucine zipper transcription factor that plays ...