LHF-535 protects AG129 mice against lethal Tacaribe virus challenge.

Mice were challenged with 200 plaque-forming units (PFU) of Tacaribe virus by intraperitoneal injection. Mice received daily oral doses of LHF-535 (3, 10, or 30 mg/kg) or vehicle alone beginning 0.5 h prior to challenge until 13 days post-challenge. One cohort (n = 8 animals per group) was monitored for survival (A), while another cohort (n = 4 animals per group) was sacrificed at 7 days post-challenge to measure viral titers in plasma (B), spleen (C), and liver (D). The virus detection limit is indicated by a dashed line.