Regioselective and Enantioselective Cu(II)-Catalyzed 1,4-Conjugate Addition of Diethylzinc Reagent to Nitrodienes
- Rukeya Rexiti (6244136)
- Zhen-Guo Zhang (6244139)
- Jian Lu (51707)
- Feng Sha (1559692)
- Xin-Yan Wu (1490878)
Publication date
January 2019
DOI Publisher
American Chemical Society (ACS)Abstract
The regioselective and enantioselective Cu(II)-catalyzed 1,4-conjugate addition of diethylzinc reagent to nitrodienes is described. With 0.25 mol % of Cu(OAc)2 and chiral amidophosphine ligand L3, the 1,4-addition products were produced with a complete regioselectivity, high yields (81–98%), and excellent enantioselectivities (87–97% ee) in a short reaction time
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